Administration Device Mixing Active Substance Dilution Liquid
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Solution Overview
Problem
Existing administration devices risk ineffective mixing of active substances with dilution liquids due to gas buildup and partial mixing, leading to potential skin injection of unmixed fluids.
Innovation Solution
An administration device with a container having separate chambers for active substances and dilution liquids, connected via a bypass, and a mixing mechanism that ensures the injection needle is inserted before mixing, allowing gas escape, and includes a blocking unit for complete mixing verification before injection.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Loss of time
If the user attempts to mix the active substance with the dilution liquid before the needle is thrust into the two-chamber cartridge, then the mixing process can be initiated early, but gas formed during mixing cannot escape and effective mixing is hindered
Solution Approach 1:
The injection needle is pre-installed in the injection needle unit before the mixing process begins. The proximal needle portion is positioned to pierce the membrane upon engagement with the cartridge, ensuring the gas escape path is established before mixing starts. This preliminary arrangement of the needle allows gas to escape during mixing without delaying the mixing process.
Solution Approach 2:
The membrane acts as an intermediary element that separates the mixing chamber from the gas escape path through the injection needle. During mixing, gas can pass through the membrane and out via the needle, while the liquid mixture remains contained. This intermediary structure enables simultaneous mixing and gas venting.
2Productivity
If mixing is performed without ensuring complete mixing, then the administration process can be completed faster, but partially mixed active substance may be injected into the skin
Solution Approach 1:
The blocking unit provides tactile feedback to the user during the mixing process. As the container is rotated relative to the mixing device, the blocking unit engages and disengages at specific positions, giving the user feedback on the mixing progress. This feedback mechanism ensures the user can detect when complete mixing has been achieved before proceeding to injection.
Solution Approach 2:
The blocking unit dynamically changes its position relative to the release knob during mixing. It blocks the release knob initially and only allows release after a specific rotational movement corresponding to complete mixing. This dynamic blocking mechanism prevents premature injection while allowing fast administration once mixing is complete.
3Reliability
If a blocking unit is added to prevent injection before complete mixing, then injection safety is improved, but device complexity increases
Solution Approach 1:
The blocking unit is merged with the release knob mechanism. The blocking unit and release knob form an integrated assembly where the blocking function is combined with the injection release function. This merging reduces the number of separate components and simplifies the overall device structure while maintaining the safety function.
Solution Approach 2:
The blocking unit serves multiple functions: it blocks premature injection, provides mixing progress feedback through engagement/disengagement, and works with the release knob to enable injection only after complete mixing. This multi-functionality reduces the need for separate safety mechanisms, thereby limiting the increase in device complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Ensures thorough mixing and priming of active substances with dilution liquids, preventing gas buildup and ensuring safe, complete administration by requiring complete mixing before allowing injection.
Implementation Method 1
By a movement of the container relative to the mixing device, the second stopper and the first stopper can be pushed within the container as a result of the transfer of the force of the dilution liquid in the second chamber
Implementation Method 2
the chambers can be connected, via a bypass, in one wall, so as to make possible a mixing of the active substance with the dilution liquid
Implementation Method 3
During the mixing operation, the container can move axially, relative to the piston rod and the housing, and can preferably rotate
Implementation Method 4
the proximal needle portion, which, in the initial position of the administration device, lies opposite, facing the membrane, and in the mixing position is thrust, through the membrane, into the container
Data Source
AI summary
An administration device comprises a container and a mixing device for mixing an active substance (in a first chamber) with a dilution liquid (in a second chamber). The container has a membrane seal at one end and is combined with a mixing device for mixing the active substance. The administration device has an injection needle unit with a distal needle portion facing away from the container for piercing the skin, and disposed opposite thereto is a proximal needle portion facing the membrane when the administration device is in the initial position, which is thrust through the membrane into the container in a mixing position. The administration device includes a protective sleeve arranged coaxially about the injection needle, movable from the initial position only in the proximal direction relative to the container. The protective sleeve can be non-rotatably connected to the container in the mixing position and rotated relative to the mixing device to perform mixing.