Penis Enlargement via ADRC Graft and Mechanical Cell Separation

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Solution Overview

Problem

Penis augmentation poses unique challenges due to the lack of adipose tissue, making fat grafting viability an issue, as adipose tissue is essential for the survival and vascularization of grafts, and existing methods are not effective for penis enlargement.

Innovation Solution

A method involving the administration of a graft enriched with adipose-derived regenerative cells (ADRCs) and stromal vascular fraction (SVF) obtained without enzymatic digestion, delivered under the deep fascia of the penis, using a SPING device for enhanced mechanical separation with minimal cell trauma, which can include autologous or allogenic grafts and adipose tissue.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Volume of moving object

If fat grafting is performed on the penis, then volume increase is achieved, but graft viability fails due to lack of adipose tissue environment

Engineering Contradiction:

Improvepenis volumeVSAvoidgraft viability

Core Design Contradiction:

Volume of moving objectVSReliability

Solution Approach 1:

The invention extracts adipose-derived regenerative cells (ADRCs) and stromal vascular fraction (SVF) from adipose tissue harvested from other body sites (abdomen, thighs, flanks). These extracted cells are then injected into the penis, providing the regenerative capacity without requiring the transplantation of bulk adipose tissue that would lack vascularization support.

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The invention separates the beneficial regenerative components (ADRCs and SVF) from the bulk adipose tissue matrix. This segmentation allows the penile tissue to receive the regenerative cells while avoiding the problems of bulk fat grafting, including the need for extensive vascularization and the risk of oil cyst formation.

Inventive Principle:

Principle #1Segmentation

2Productivity

If enzymatic digestion is used to obtain SVF, then cell separation is efficient, but cell trauma increases reducing viability

Engineering Contradiction:

Improvecell separation efficiencyVSAvoidcell viability

Core Design Contradiction:

ProductivityVSReliability

Solution Approach 1:

The invention replaces enzymatic digestion with a mechanical separation system (SPING device) that uses controlled mechanical forces to separate SVF from adipose tissue. This mechanical approach avoids the cytotoxic effects of enzymes while achieving efficient cell separation, as evidenced by higher viability rates compared to enzymatic methods.

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This method enhances penis enlargement by providing viable ADRCs and SVF, promoting tissue regeneration with reduced cell trauma, as demonstrated by higher cell yields and viability compared to traditional methods, effectively addressing the challenge of adipose tissue scarcity on the penis.

Implementation Method 1

enhanced mechanical separation with minimal cell trauma

Methodology Applied

Scientific EffectMechanical separation: Mechanical Force

Data Source

PatentUS20220133954A1Penis augmentation

Publication Date: 2022.05.05 THE DUKE LTD

AI summary

The present invention provides a method of penis enlargement. The method comprises administering to a site of penis of a subject a graft enriched with adipose derived regenerative cells.