Water-Insoluble Adsorbent for Calciprotein Particle Removal
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Solution Overview
Problem
Current methods are ineffective in directly reducing calciprotein particles in the blood and removing them from body fluids, particularly for patients with advanced arterial sclerosis and chronic kidney disease, as they cannot be efficiently controlled or removed by existing treatments.
Innovation Solution
A water-insoluble adsorbent with a hydrocarbon group covalently bonded to electron-donating groups such as phosphate or carboxyl groups is used to adsorb calciprotein particles, enhancing their removal from body fluids through a process involving a container packed with the adsorbent and connected to a dialyzer or plasma separator.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional treatments (antiplatelet drugs, phosphate binders, dialysis) are used, then some risk control is achieved, but calciprotein particles cannot be effectively removed from body fluid
Solution Approach 1:
The patent introduces a water-insoluble carrier with specific surface functional groups (amino, carboxyl, phosphate, phosphono, phosphino, or thiol groups) as an intermediary substance that selectively adsorbs calciprotein particles from body fluid. This intermediary agent bridges the gap between existing treatments and the unmet need for direct CPP removal, enabling effective elimination of calciprotein particles without relying solely on conventional methods like dialysis.
2Quantity of substance
If no specific adsorbent is used, then existing treatments are simple to implement, but calciprotein particles accumulate in the blood
Solution Approach 1:
The patent employs a water-insoluble carrier with porous structure that provides large surface area for adsorption. The porous material allows body fluid to permeate through while providing extensive surface area with functional groups for binding calciprotein particles, thereby achieving effective particle removal while maintaining a practical device configuration suitable for medical applications.
Solution Approach 2:
The adsorbent is constructed as a composite material combining a water-insoluble carrier matrix with surface-bound functional groups. This composite structure integrates the mechanical stability of the insoluble carrier with the selective binding capability of the functional groups (amino, carboxyl, phosphate, phosphono, phosphino, or thiol), creating a material that is both structurally sound and functionally effective for CPP adsorption.
3Ease of operation
If a water-soluble adsorbent is used, then the adsorbent is easy to administer, but it cannot be effectively packed in a container for continuous adsorption
Solution Approach 1:
Instead of using a water-soluble adsorbent that would dissolve and be difficult to retain in a container, the patent inverts the approach by employing a water-insoluble carrier. This insoluble carrier can be readily packed into a container to form a packed bed that allows continuous flow of body fluid through it, enabling sustained adsorption of calciprotein particles over time while maintaining ease of administration through simple container packing.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The adsorbent effectively adsorbs calciprotein particles, improving their removal from body fluids and potentially aiding in the treatment of related diseases by increasing the interaction efficiency between the adsorbent and calciprotein particles.
Implementation Method 1
a surface of the water-insoluble carrier is covalently bonded, through a hydrocarbon group, to at least one selected from the group consisting of amino groups, carboxyl groups, phosphate groups, phosphono groups, phosphino groups, and thiol groups
Implementation Method 2
a surface of the water-insoluble carrier is covalently bonded, through a hydrocarbon group, to at least one selected from the group consisting of amino groups, carboxyl groups, phosphate groups, phosphono groups, phosphino groups, and thiol groups
Data Source
AI summary
The purpose of the present invention is to adsorb calciprotein particles. An adsorbent for calciprotein particles of the present invention is characterized in that the surface of a water-insoluble carrier is covalently bonded, through a hydrocarbon group, to at least one selected from the group consisting of amino group, carboxyl group, phosphate group, phosphono group, phosphino group, and thiol group.