Adsorption Column Angular Lid Design for Elution Peak Purification
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Solution Overview
Problem
Existing adsorption apparatuses using hydroxyapatite as an adsorbent face challenges in achieving an excellent purification rate due to trailing skirt in the peak of eluted substances, leading to inefficiencies in isolating bio-based pharmaceuticals.
Innovation Solution
The design of a column with specific angular configurations for its lids and partition walls, ensuring that angles θ1 and θ2 between the lids and partition walls fall within the range of 7.5° to 20°, which reduces trailing skirt and enhances purification efficiency.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If a conventional column structure with flat lids and partition walls is used, then the device complexity is low and ease of manufacture is high, but trailing skirt occurs in the peak of eluted substances leading to insufficient purification rate
Solution Approach 1:
The invention changes the geometric parameters of the column structure by specifying that the lid surface and partition wall surface form an angle θ of 5° to 15° relative to the horizontal plane. This parameter modification optimizes the flow distribution of the sample solution, reduces trailing skirt in the elution peak, and improves purification rate without fundamentally altering the column's basic structure.
Solution Approach 2:
The invention introduces a new dimensional consideration by tilting the lid and partition wall surfaces from the horizontal plane, adding an angular dimension to the traditionally flat-column design. This dimensional change creates more uniform flow paths and eliminates dead zones, thereby improving elution efficiency and purification rate.
2Productivity
If the angle between lid surface and partition wall surface is increased to reduce trailing skirt, then purification rate improves, but manufacturing precision requirements increase
Solution Approach 1:
The invention optimizes the angle parameter to a moderate range of 5° to 15°, which is sufficient to reduce trailing skirt and improve purification rate while remaining practical for manufacturing. This parameter selection balances performance improvement with manufacturing feasibility, avoiding excessively tight tolerance requirements.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This configuration significantly reduces trailing skirt in the peak of eluted substances, thereby improving the purification rate of bio-based pharmaceuticals in adsorption apparatuses.
Implementation Method 1
the substance to be adsorbed as an isolation material contained in the sample solution specifically adsorbs with its inherent adsorption force (carrying force)
Data Source
AI summary
Object: To provide a column for use in an adsorption apparatus capable of purifying and isolating a substance to be adsorbed, which is contained in a sample solution, at an excellent purification rate, and an adsorption apparatus including the column. Resolution means: A column 2 of the present invention includes: a column main body 21; filter members 4 and 5 (first partition wall and second partition wall) that define an adsorbent filling space 20; a lid 26 (first lid) having a flow path 41 (first flow path) defining a space 262 (first space) between the lid 26 and the filter member 4; a lid 27 (second lid) having a flow path 51 (second flow path) defining a space 272 (second space) between the lid 27 and the filter member 5. The lids 26 and 27 have first and second lid surfaces facing the spaces 262 and 272, respectively. An angle θ1 [°] formed by a first partition wall surface of the filter member 4 and the first lid surface, and an angle θ2 formed by a second partition wall surface of the filter member 5 and the second lid surface satisfy at least one of 7.5°≤θ1≤20° and 7.5°≤θ2≤20°.