Aerosol Delivery Valve Control for Precise Mucosal Absorption
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Solution Overview
Problem
Existing devices for delivering aerosolized substances to natural body orifices either focus on improving aerosol formation and dispersion or formulation for better absorption, neglecting the need for efficient delivery and absorption into and through the mucosal layer.
Innovation Solution
A device with a valve mechanism that allows precise control over delivery configuration, using pressurized gas to entrain the substance and deliver it through a defined orifice, optimizing parameters like pressure, volume, and time to achieve efficient delivery and absorption.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If improvements are made to the delivery device to enhance aerosol formation and dispersion, then aerosol delivery capability is improved, but absorption into and through the mucosal layer is neglected
Solution Approach 1:
The patent changes physical parameters of the delivery system including pressurized gas pressure (1-10 barg), delivery volume (1-21 ml), and delivery time (0-500 ms) to optimize both aerosol formation and mucosal absorption simultaneously, resolving the contradiction between delivery capability and absorption reliability
2Reliability
If improvements are made to the formulation to enhance absorption into the mucosal layer, then absorption capability is improved, but delivery of sufficient material to the desired tissue is neglected
Solution Approach 1:
The patent employs a pressurized gas system with controlled pressure (1-10 barg) and volume (1-21 ml) to deliver the formulated substance deep into body orifices, ensuring sufficient material delivery to target tissues while maintaining enhanced absorption properties of the formulation
3Speed
If the valve is reconfigured quickly from inactive to active configuration, then delivery speed is improved, but control precision may be compromised
Solution Approach 1:
The patent uses a dynamically reconfigurable valve mechanism that can transition between inactive and active configurations within a controlled time frame (0-500 ms), allowing rapid delivery while maintaining precision through defined pressure and volume parameters
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device ensures accurate and reproducible delivery of aerosolized substances deep into body orifices, enhancing absorption at the target site, such as the nasal cavity, with controlled particle size and velocity, improving uptake to tissues like the brain.
Implementation Method 1
the device is configured, once the valve is reconfigured from the INACTIVE CONFIGURATION to the ACTIVE CONFIGURATION, to entrain the substance by the pressurized gas, and deliver the same via the orifice in the delivery end within the body cavity
Data Source
AI summary
A device for delivering a predetermined volume a substance within a body cavity. The device includes: at least one predefined volume sized and shaped to contain a predetermined volume the substance; a delivery end in fluid communication with a container; and at least one valve mechanically connected to the container and configurable between an active configuration in which the valve enables delivery of a volume of the substance and an inactive configuration, in which the valve prevents delivery.