Aerosol Generator Selective Decarboxylation Control
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Solution Overview
Problem
Current aerosol delivery systems for inhalation do not effectively control the decarboxylation of carboxylated cannabinoids, which affects the stability and pharmacological efficacy of cannabinoids like CBDA and CBD, as they exert greater pharmacological effects in their decarboxylated form.
Innovation Solution
A powered aerosol generating device with a controller that allows for selective decarboxylation of carboxylated cannabinoids by varying the power level to the aerosol generator, such as a heater, enabling users to control the conversion of CBDA to CBD based on power profiles and inhalation parameters.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If carboxylated cannabinoids are used in aerosolizable material, then stability profile is improved, but pharmacological efficacy is reduced
Solution Approach 1:
The system performs preliminary decarboxylation by heating the carboxylated cannabinoids in the aerosolizable material before aerosolization. The controller manages heating power levels to convert CBDA to CBD in advance, ensuring both stability during storage and pharmacological efficacy when delivered to the user.
Solution Approach 2:
The system changes the temperature parameter during aerosolization to control the decarboxylation process. By adjusting the heating power level dynamically, the system optimizes the conversion of carboxylated to decarboxylated cannabinoids, balancing stability and efficacy based on real-time conditions.
2Reliability
If heating power level is increased to promote decarboxylation, then pharmacological efficacy is improved, but energy consumption increases
Solution Approach 1:
The controller dynamically adjusts the heating power level based on the desired decarboxylation extent and real-time operating conditions. This dynamic control allows the system to use higher power only when necessary for effective decarboxylation, optimizing the balance between pharmacological efficacy and energy consumption.
Solution Approach 2:
The system applies heating in periodic cycles rather than continuous high-power heating. The controller manages power delivery in controlled intervals, allowing decarboxylation to proceed effectively while reducing overall energy consumption compared to sustained high-power operation.
3Reliability
If decarboxylation is allowed to proceed extensively, then pharmacological efficacy is improved, but stability of the aerosolizable material deteriorates
Solution Approach 1:
The system carefully controls the temperature parameter during heating to achieve the desired degree of decarboxylation without excessive heat exposure. By adjusting power levels and heating duration, the system maximizes pharmacological efficacy while maintaining material stability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables precise control over the decarboxylation process, allowing for varying amounts of decarboxylated cannabinoids in the aerosol, enhancing user experience by optimizing the pharmacological effect and stability of cannabinoids.
Implementation Method 1
an aerosol generator that is capable of converting an aerosolizable material into an aerosol. In some instances, the aerosol generated is a condensation aerosol whereby an aerosolizable material is first vaporized and subsequently allowed to condense into an aerosol
Implementation Method 2
the system is configured to provide for selective decarboxylation of the carboxylated active... providing a higher power to an aerosol generator, e.g. a heater, will generally result in a higher localized temperature at the heater meaning that conversion from the carboxylated form to the decarboxylated form will generally be greater
Data Source
AI summary
A delivery system including an electrically powered aerosol generating device and an aerosolizable material, wherein the aerosolizable material includes at least one cannabinoid present in carboxylated form, and wherein the system is configured to provide for selective decarboxylation of the carboxylated form.