Aerosolization System Flow Restrictor Feedback

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Solution Overview

Problem

Current aerosolization systems deliver inconsistent medicament doses, often with too great or too little force, leading to incomplete delivery and contamination issues, as they fail to ensure accurate aerosolization and proper inhalation flow rates for effective respiratory system treatment.

Innovation Solution

An aerosolization system that includes a vibratable mesh and flow sensor to measure inhalation flow rates, providing visual indications through lights to guide users on maintaining optimal flow rates between 7 and 14 L/min, ensuring complete aerosolization and minimizing contamination by preventing excessive or insufficient airflow.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Speed

If aerosolization systems deliver medicament with high force, then aerosolization speed is improved, but medicament may not be properly delivered to respiratory system and contamination increases

Engineering Contradiction:
Improveaerosolization speedVSAvoidcontamination
Core Design Contradiction:
SpeedVSObject-affected harmful factors

Solution Approach 1:

The patent implements feedback control by monitoring airflow rate and providing visual feedback to the user through lights. The system measures the user's inhalation flow rate and compares it to the optimal range (7-14 L/min), then provides real-time feedback through different light patterns (green for optimal, yellow for too fast, red for too slow). This ensures the user adjusts their inhalation to achieve proper aerosolization without contamination.

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

The patent specifies precise parameter ranges for optimal operation, particularly airflow rate (7-14 L/min) and aerosol particle size (1-5 micrometers). By controlling these parameters within defined ranges, the system achieves effective aerosolization while preventing contamination and ensuring proper respiratory delivery.

Inventive Principle:
Principle #35Parameter changes

2Device complexity

If aerosolization systems use simple delivery mechanism, then device complexity is reduced, but dose delivery consistency deteriorates

Engineering Contradiction:
Improvedelivery mechanism complexityVSAvoiddose delivery consistency
Core Design Contradiction:
Device complexityVSManufacturing precision

Solution Approach 1:

The system uses feedback control to maintain dose delivery consistency without requiring complex mechanical mechanisms. By monitoring airflow rate and providing real-time visual feedback to the user, the system ensures consistent inhalation patterns and complete medicament delivery, achieving precision through control rather than mechanical complexity.

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

The patent replaces complex mechanical dose control mechanisms with an electronic sensing and feedback system. Instead of using intricate mechanical valves or regulators, the system uses airflow sensors and visual feedback to guide the user's inhalation, achieving consistent dose delivery through electronic control and user guidance rather than mechanical complexity.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

3Loss of time

If aerosolization systems allow rapid inhalation, then treatment time is reduced, but flow rate exceeds optimal range and delivery effectiveness decreases

Engineering Contradiction:
Improvetreatment timeVSAvoiddelivery effectiveness
Core Design Contradiction:
Loss of timeVSReliability

Solution Approach 1:

The system provides real-time feedback on inhalation flow rate through visual indicators. When the user inhales too quickly (exceeding 14 L/min), the system displays yellow or red lights to signal that the flow rate is outside the optimal range. This immediate feedback allows the user to adjust their inhalation speed to maintain effectiveness while minimizing treatment time.

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

The system dynamically adapts to the user's inhalation pattern by providing real-time feedback that guides the user to achieve the optimal flow rate range. The feedback mechanism allows the user to dynamically adjust their breathing to match the optimal parameters, ensuring both speed and effectiveness.

Inventive Principle:
Principle #15Dynamics

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The system ensures consistent and complete delivery of medicaments to the respiratory system by optimizing airflow rates, reducing contamination, and enhancing user guidance for proper inhalation techniques, thereby improving treatment efficacy.

Implementation Method 1

actuating a vibratable element to vibrate the mesh, causing aerosolization of liquid medicament and creating a plume of aerosolized liquid medicament in the flowing air

Methodology Applied
Scientific EffectAerosolization: Aerosol

Data Source

PatentUS11273271B2Aerosolization system with flow restrictor and feedback device
Publication Date: 2022.03.15 AERAMI THERAPEUTICS INC
  • US11273271B2 patent drawing
  • US11273271B2 patent drawing
  • US11273271B2 patent drawing

AI summary

In one aspect, embodiments of the present invention provide an aerosolization device for ensuring proper delivery of an aerosolized medication to a user's respiratory system. The aerosolization device may include a conduit, an aerosol generator, a restrictor disposed within the conduit, and an indicator mechanism. The conduit may include a mouthpiece end by which a user may cause inspiratory flow through the conduit. The aerosol generator may include a vibratable mesh. The restrictor may define a plurality of apertures disposed along an outer periphery of the restrictor configured to provide an increase in pressure differential that varies with an inspiratory flow rate within the conduit and to provide a relatively laminar flow downstream of the restrictor compared to upstream of the restrictor. The indicator mechanism may indicate to a user a state of a parameter of the inspiratory flow relative to a predefined desired range.