Ag/AgCl Reference Electrode Lifetime Extension

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Solution Overview

Problem

The lifetime of Ag/AgCl reference electrodes in implantable biosensors is limited due to dissolution in the surrounding tissue, restricting their use in long-term applications.

Innovation Solution

The use of a dielectric layer or permselective coating to protect the Ag/AgCl surface, or applying an electrical potential to regenerate AgCl, extends the reference electrode's lifespan by preventing dissolution and maintaining a stable potential.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Duration of action of stationary object

If the amount of Ag/AgCl loaded on the reference electrode is increased to prolong lifetime, then the lifetime is extended, but the sensor size and compactness are compromised

Engineering Contradiction:
Improvereference electrode lifetimeVSAvoidsensor size
Core Design Contradiction:
Duration of action of stationary objectVSArea of stationary object

Solution Approach 1:

The patent applies preliminary action by pre-charging the reference electrode with a substantial amount of Ag/AgCl material before implantation. This initial loading ensures that the electrode has sufficient active material to maintain stable potential throughout the entire sensor lifetime (weeks to months), eliminating the need for size increases during operation. The Ag/AgCl is deposited in advance onto the electrode substrate, creating a reservoir that slowly dissolves to maintain potential stability over extended periods.

Inventive Principle:
Principle #10Preliminary action

2Reliability

If Ag/AgCl is used as the reference electrode material, then the electrode provides stable potential, but the electrode dissolves in surrounding tissue limiting lifetime

Engineering Contradiction:
Improvepotential stabilityVSAvoidAgCl dissolution
Core Design Contradiction:
ReliabilityVSLoss of substance

Solution Approach 1:

The patent applies parameter changes by modifying the physical and chemical parameters of the Ag/AgCl electrode system. Specifically, it changes the surface area to volume ratio by using a porous or high-surface-area substrate, and adjusts the Ag/AgCl layer thickness and composition ratios. These parameter modifications allow the electrode to dissolve at a controlled rate that maintains potential stability while extending lifetime. The patent may also adjust the chloride ion concentration in the electrolyte or modify the Ag/AgCl crystal structure to reduce dissolution rate.

Inventive Principle:
Principle #35Parameter changes

3Duration of action of moving object

If the sensor is designed for long term use in vivo, then the application duration is extended, but the Ag/AgCl dissolution accelerates

Engineering Contradiction:
Improvesensor operational durationVSAvoidAgCl dissolution rate
Core Design Contradiction:
Duration of action of moving objectVSLoss of substance

Solution Approach 1:

The patent applies continuity of useful action by designing the Ag/AgCl electrode to provide continuous potential stability throughout the entire sensor operational lifetime. The electrode is engineered with a controlled dissolution rate that continuously replenishes the Ag/AgCl surface while maintaining the necessary potential stability. This continuous action allows the sensor to operate for weeks to months without signal drift or potential instability, as the Ag/AgCl dissolution provides a steady, sustained effect rather than a temporary one.

Inventive Principle:
Principle #20Continuity of useful action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

These methods significantly increase the stability and longevity of Ag/AgCl reference electrodes, enabling extended use in implantable biosensors by reducing AgCl dissolution and maintaining a stable potential over time.

Implementation Method 1

The reference electrode is typically composed of Ag/AgCl, which is fabricated via screen printing or electroplating. However, the lifetime of a screen-printed Ag/AgCl reference electrode is typically limited in an in vivo amperometric sensor due to dissolution of the AgCl into the surrounding tissue.

Methodology Applied
Scientific EffectPhysical barrier (dielectric layer): Physical Containment

Implementation Method 2

The use of a dielectric layer or permselective coating to protect the Ag/AgCl surface, or applying an electrical potential to regenerate AgCl, extends the reference electrode's lifespan by preventing dissolution and maintaining a stable potential.

Methodology Applied
Scientific EffectSelective permeability (permselective coating): Semipermeable Membrane

Implementation Method 3

applying an electrical potential to regenerate AgCl, extends the reference electrode's lifespan by preventing dissolution and maintaining a stable potential

Methodology Applied
Scientific EffectElectrochemical regeneration: Electrolysis

Implementation Method 4

In an example of an amperometric glucose biosensor, glucose is oxidized by oxygen in the body fluid via a glucose oxidase-catalyzed reaction that generates gluconolactone and hydrogen peroxide, then the hydrogen peroxide is electrooxidized and correlated to the concentration of glucose in the body fluid.

Methodology Applied
Scientific EffectElectrochemical reaction: Redox Reactions

Data Source

PatentUS8155722B2Reference electrodes having an extended lifetime for use in long term amperometric sensors
Publication Date: 2012.04.10 ABBOTT DIABETES CARE INC
  • US8155722B2 patent drawing
  • US8155722B2 patent drawing
  • US8155722B2 patent drawing

AI summary

The present application provides Ag/AgCl based reference electrodes having an extended lifetime that are suitable for use in long term amperometric sensors. Electrochemical sensors equipped with reference electrodes described herein demonstrate considerable stability and extended lifetime in a variety of conditions.