Agaricus blazei Murill Composition Synergistic Amino Acid Enhancement
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Solution Overview
Problem
Current compositions comprising Agaricus blazei Murill or its extracts and amino acids from the ornithine cycle lack synergistic enhancement of pharmacological activities, particularly in antitumor effects.
Innovation Solution
A composition combining Agaricus blazei Murill or its extract with an amino acid from the ornithine cycle, such as arginine, ornithine, or citrulline, in specific weight ratios, enhancing pharmacological activities through synergistic effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If Agaricus blazei Murill or its extract is combined with amino acids from the ornithine cycle, then pharmacological activities are enhanced, but the composition complexity increases
Solution Approach 1:
The patent combines Agaricus blazei Murill (or its extract) with amino acids from the ornithine cycle (arginine, ornithine, or citrulline) in a single composition. This merging of multiple pharmacologically active components creates synergistic effects that enhance antitumor activity, immune function, and other therapeutic benefits beyond what either component could achieve alone.
Solution Approach 2:
The invention creates a composite pharmaceutical composition by integrating the fruit body or extract of Agaricus blazei Murill with specific amino acids (arginine, ornithine, or citrulline) in defined weight ratios. This composite structure leverages the complementary pharmacological properties of each component to achieve enhanced therapeutic efficacy.
2Reliability
If specific weight ratios of amino acids are used to achieve synergistic effects, then pharmacological efficacy is improved, but manufacturing precision requirements increase
Solution Approach 1:
The patent specifies precise weight ratio parameters for combining Agaricus blazei Murill (or extract) with amino acids from the ornithine cycle. By defining specific quantitative relationships (e.g., weight ratios of amino acids to fruit body or extract), the invention optimizes pharmacological efficacy while providing clear manufacturing guidelines to control composition consistency.
Data Source
AI summary
The invention provides a composition containing a fruit body of Agaricus blazei murill or an extract of the fruit body, and an amino acid constituting the ornithine cycle or a salt thereof, wherein the pharmacological activities of the fruit body of Agaricus blazei murill or the extract of the fruit body and the amino acid constituting the omithine cycle or the salt thereof are increased synergistically. Such a composition can contain a fruit body of Agaricus blazei murill or an extract of the fruit body, and an amino acid constituting the ornithine cycle or a salt thereof in 10-100 parts by weight per 1 part by weight of the fruit body or the extract.