Age-Adjusted Biomarker Reference Ranges for Health Assessment
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Solution Overview
Problem
Current healthcare systems face challenges in accurately assessing an individual's health status due to variability in biological sample testing, lack of standardization, and failure to address environmental stressors, leading to suboptimal preventative measures.
Innovation Solution
A method to attribute an adjusted chronological age to individuals by measuring specific analytes (HbA1c, ASO, CRP, albumin, glucose, and cystatin C) and comparing them to reference values, using microarrays and computer programs to analyze data and provide a more accurate assessment of health status.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If population-based reference ranges are used for analyte interpretation, then standardization is simplified, but measurement precision and individualized health assessment are reduced
Solution Approach 1:
The patent adjusts the reference parameter from fixed population averages to dynamic age-adjusted references. By continuously updating reference ranges based on chronological age and comparing individual analyte trajectories against age-matched cohorts, the system achieves both standardization through systematic methodology and precision through individualized age-specific benchmarks.
2Measurement precision
If multiple analytes are measured to improve health assessment accuracy, then measurement precision increases, but device complexity and cost increase
Solution Approach 1:
The patent employs a multi-analyte panel (HbA1c, ASO, CRP, albumin, glucose, urea, cystatin C) where each analyte serves multiple functions: they individually assess different physiological systems while collectively providing a comprehensive health profile. This multi-functional approach allows a single testing system to deliver diverse health insights without requiring separate specialized tests for each parameter.
Solution Approach 2:
The patent combines multiple analyte measurements, age data, and reference range comparisons into a unified health assessment framework. By integrating these elements into a single coordinated system that evaluates all analytes together against age-adjusted benchmarks, the patent reduces the complexity that would arise from separate independent assessments while maintaining comprehensive precision.
3Ease of operation
If chronological age is used as the sole reference, then ease of operation is maintained, but measurement precision of biological age assessment is reduced
Solution Approach 1:
The patent introduces age-adjusted reference ranges as an intermediary between chronological age and biological age assessment. Instead of directly calculating biological age from complex biomarkers, the system uses chronological age to select appropriate reference ranges, then compares individual analyte levels against these references. This intermediary approach maintains operational simplicity while achieving precise biological age evaluation through the reference-mediated comparison process.
Data Source
AI summary
Methods and products for adjusting the chronological age of a biological system or an individual to provide finer scale insight to health status are provided. The methods are underpinned by various serum and urinary biomarkers including antistreptolysin.