AGE Fluorescence Estimation of Blood Glucose Spike Frequency

Solution Overview

Problem

Continuous glucose monitoring for detecting blood glucose spikes is burdensome and costly, leading to avoidance by subjects, while infrequent measurement of advanced glycation end products (AGEs) provides insufficient feedback for lifestyle habit adjustments.

Innovation Solution

An estimation method and system that utilizes a correlation between AGE measurement values and blood glucose spike frequencies to estimate the latter without continuous monitoring, using a computing device to analyze AGE data and provide estimated frequencies, risks, and lifestyle advice.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If continuous glucose monitoring is performed to detect blood glucose spikes, then measurement precision is improved, but device complexity and ease of operation worsen due to needle insertion and continuous monitoring burden

Engineering Contradiction:

Improveblood glucose spike detection accuracyVSAvoidsubject burden

Core Design Contradiction:

Measurement precisionVSEase of operation

Solution Approach 1:

The patent uses advanced glycation end products (AGEs) as an intermediary substance to indirectly estimate blood glucose spike frequency. Instead of directly measuring blood glucose continuously, the system measures AGEs accumulation in interstitial fluid, which serves as a biomarker correlated with cumulative glucose spike exposure. This mediator approach eliminates the need for continuous needle insertion while providing indirect but useful information about glucose spike patterns.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent creates a simplified copy of the continuous glucose monitoring function by using AGEs measurement. Rather than replicating the complex continuous monitoring process, it uses a different measurement (AGEs level) that correlates with the desired information (blood glucose spike frequency). This copy approach provides comparable diagnostic value with significantly reduced operational burden.

Inventive Principle:

Principle #26Copying

2Loss of information

If continuous glucose monitoring is performed to obtain blood glucose spike frequency, then information completeness is improved, but loss of time and productivity worsen due to prolonged monitoring period

Engineering Contradiction:

Improveblood glucose spike frequency informationVSAvoidmonitoring duration

Core Design Contradiction:

Loss of informationVSLoss of time

Solution Approach 1:

The patent utilizes AGEs accumulation as a preliminary integrated measure of glucose spike exposure over time. AGEs naturally accumulate in the body as a result of repeated glucose spikes, so measuring AGEs level provides a pre-integrated summary of cumulative glucose spike frequency without requiring continuous real-time monitoring. This preliminary action approach condenses time-consuming continuous monitoring into a single snapshot measurement.

Inventive Principle:

Principle #10Preliminary action

3Measurement precision

If continuous glucose monitoring is performed, then measurement precision is improved, but device complexity and cost worsen

Engineering Contradiction:

Improveblood glucose spike frequency measurementVSAvoidmonitoring system complexity

Core Design Contradiction:

Measurement precisionVSDevice complexity

Solution Approach 1:

The patent uses advanced glycation end products (AGEs) as an intermediary substance to indirectly estimate blood glucose spike frequency. Instead of directly measuring blood glucose continuously, the system measures AGEs accumulation in interstitial fluid, which serves as a biomarker correlated with cumulative glucose spike exposure. This mediator approach eliminates the need for continuous needle insertion while providing indirect but useful information about glucose spike patterns.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent creates a simplified copy of the continuous glucose monitoring function by using AGEs measurement. Rather than replicating the complex continuous monitoring process, it uses a different measurement (AGEs level) that correlates with the desired information (blood glucose spike frequency). This copy approach provides comparable diagnostic value with significantly reduced operational burden.

Inventive Principle:

Principle #26Copying

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables the recognition of blood glucose spike frequencies and associated diabetes risks with reduced burden on subjects, allowing for lifestyle adjustments based on non-invasive AGE measurements.

Implementation Method 1

a sensor that receives fluorescence excited by light applied to the skin of a subject and measures a degree of accumulation of AGEs based on the intensity of the received fluorescence

Methodology Applied

Scientific EffectFluorescence: Fluorescence

Data Source

PatentUS20250331739A1Estimation Method, Estimation Program, Estimation System, Determination Method, and Estimation Marker

Publication Date: 2025.10.30 SHIMADZU CORP

AI summary

An estimation method includes: obtaining a measurement value of advanced glycation end products of a subject; and estimating, using a correlation between a measurement value of advanced glycation end products and a blood glucose spike frequency prepared in advance, a blood glucose spike frequency of the subject based on the measurement value of advanced glycation end products of the subject obtained in the obtaining.