Alanylglutamine Composition for Vision Performance During Exercise

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Solution Overview

Problem

Vision performance, particularly peripheral vision and visual reaction time, declines during physical exertion, and existing compositions do not effectively enhance these aspects.

Innovation Solution

A composition containing alanylglutamine or its salt as an active ingredient, administered through various pharmaceutical preparations, including oral and parenteral forms, to improve vision performance by enhancing peripheral vision and visual reaction time during exercise.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If glutamine is used as a nutritional supplement, then it can supply glutamine for physiological functions, but it has low solubility and poor stability in aqueous solutions

Engineering Contradiction:
Improveglutamine supplyVSAvoidstability in aqueous solution
Core Design Contradiction:
Quantity of substanceVSStability of the object's composition

Solution Approach 1:

The patent combines glutamine with alanine to form alanylglutamine, a dipeptide composite material. This composite structure improves both solubility and stability in aqueous solutions compared to free glutamine, while still providing glutamine for physiological functions after degradation in the body.

Inventive Principle:
Principle #40Composite materials

Solution Approach 2:

The patent changes the chemical form of glutamine from a free amino acid to a dipeptide compound (alanylglutamine). This parameter change in molecular structure fundamentally improves the solubility and stability characteristics while maintaining the biological functionality of glutamine.

Inventive Principle:
Principle #35Parameter changes

2Stability of the object's composition

If alanylglutamine is used instead of glutamine, then solubility and stability are improved, but there is no known action to enhance vision performance

Engineering Contradiction:
Improvesolubility and stabilityVSAvoidvision performance enhancement
Core Design Contradiction:
Stability of the object's compositionVSReliability

Solution Approach 1:

The patent discovers that alanylglutamine naturally degrades into alanine and glutamine in the body, and the glutamine released from this degradation serves the vision performance enhancement function. The compound essentially serves itself by breaking down into the active component needed for the desired effect.

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

Alanylglutamine acts as an intermediary compound that delivers glutamine to the body in a stable, soluble form. It mediates between the need for stable glutamine delivery and the biological requirement for glutamine to enhance vision performance during exercise.

Inventive Principle:
Principle #24Intermediary (Mediator)

3Quantity of substance

If existing nutritional compositions are used during exercise, then general nutritional needs are met, but vision performance particularly peripheral vision and visual reaction time declines

Engineering Contradiction:
Improvenutritional supplyVSAvoidvisual reaction time
Core Design Contradiction:
Quantity of substanceVSSpeed

Solution Approach 1:

The patent administers alanylglutamine before exercise to preemptively maintain vision performance. The compound is taken in advance to ensure adequate glutamine levels are available during exercise, preventing the decline in visual reaction time and peripheral vision that would otherwise occur.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The patent changes the nutritional approach from general amino acid supplementation to specifically using alanylglutamine, which provides stable glutamine delivery. This parameter change in the nutritional composition specifically addresses vision performance maintenance during exercise.

Inventive Principle:
Principle #35Parameter changes

Data Source

PatentEP2819685B1Use of alanylglutamine for enhancing vision performance
Publication Date: 2018.04.18 KYOWA HAKKO BIO CO LTD
  • EP2819685B1 patent drawingFigure 1
  • EP2819685B1 patent drawingFigure 2
  • EP2819685B1 patent drawingFigure 3

AI summary

A vision performance enhancing composition and method to enhance vision performance using alanylglutamine or a salt of alanylglutamine as an active ingredient.