Albiflorin Multi-Target Therapy for IBS Side Effects

Solution Overview

Problem

Current treatments for irritable bowel syndrome (IBS) lack an efficient, multi-functional drug that effectively addresses antidepressant, antianxiety, anti-inflammatory, antidiarrheal, analgesic, and gastrointestinal regulatory effects while minimizing side effects and economic burden.

Innovation Solution

Albiflorin or its pharmaceutically acceptable salt is used in a medicament or health-care food to treat IBS, offering multiple functions with minimal side effects and long-term safety, formulated into various dosage forms using a carrier and derived from Paeonia lactiflora Pall or P. suffruticosa Andrz.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If combined administration of multiple drugs (antidepressant + antianxietic + gastrointestinal drugs) is used to treat IBS, then the efficacy is improved to a certain extent, but the side effects are superimposed and the cost increases

Engineering Contradiction:

ImproveefficacyVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent applies the universality principle by using albiflorin as a single compound that performs multiple therapeutic functions simultaneously. Albiflorin exhibits antidepressant, antianxietic, anti-inflammatory, antidiarrheal, analgesic, and gastrointestinal regulatory effects, thereby replacing the need for combined administration of multiple specialized drugs while maintaining comprehensive efficacy and reducing side effect accumulation

Inventive Principle:

Principle #6Universality (Multi-functionality)

2Reliability

If combined administration of multiple drugs is used to treat IBS, then the efficacy is improved to a certain extent, but the cost of treatment increases and economic burden increases

Engineering Contradiction:

ImproveefficacyVSAvoidcost

Core Design Contradiction:

ReliabilityVSQuantity of substance

Solution Approach 1:

The patent applies the universality principle by using albiflorin as a single compound that performs multiple therapeutic functions simultaneously. Albiflorin exhibits antidepressant, antianxietic, anti-inflammatory, antidiarrheal, analgesic, and gastrointestinal regulatory effects, thereby replacing the need for combined administration of multiple specialized drugs while maintaining comprehensive efficacy and reducing side effect accumulation

Inventive Principle:

Principle #6Universality (Multi-functionality)

3Adaptability or versatility

If symptomatic treatment with multiple types of drugs is used, then different symptoms are addressed, but no single efficient drug exists and treatment complexity increases

Engineering Contradiction:

Improvesymptom coverageVSAvoidtreatment complexity

Core Design Contradiction:

Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The patent applies the universality principle by using albiflorin as a single compound that performs multiple therapeutic functions simultaneously. Albiflorin exhibits antidepressant, antianxietic, anti-inflammatory, antidiarrheal, analgesic, and gastrointestinal regulatory effects, thereby replacing the need for combined administration of multiple specialized drugs while maintaining comprehensive efficacy and reducing side effect accumulation

Inventive Principle:

Principle #6Universality (Multi-functionality)

Data Source

PatentUS10350230B2Use of albiflorin or pharmaceutically acceptable salt for prevention and/or treatment of irritable bowel syndrome

Publication Date: 2019.07.16 ZHANG ZUOGUANG

AI summary

Disclosed is a use of albiflorin or a pharmaceutically acceptable salt for the prevention and/or treatment of irritable bowel syndrome. The experimental results demonstrate that the prevention, remission and/or treatment of irritable bowel syndrome with albiflorin or a pharmaceutically acceptable salt has significant effects and few side effects. This is a preparation derived from a natural plant for the safe, effective and multi-targeted prevention, remission and/or treatment of irritable bowel syndrome.