ALD Coated Wound Care Device for Controlled Drug Release

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Solution Overview

Problem

Current wound care products lack effective controlled drug release systems for extended periods, failing to provide a consistent or dynamically modified release of medications during various phases of wound repair.

Innovation Solution

A device with a coating film comprising metal oxides like aluminium oxide, titanium oxide, or silicon oxide, combined with sensors and circuitry for detecting skin conditions, enabling controlled release of biologically active compounds and antimicrobial substances, and utilizing atomic layer deposition for precise drug delivery.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Duration of action of moving object

If conventional wound care products are used, then basic wound protection is provided, but controlled drug release over extended periods cannot be achieved

Engineering Contradiction:

Improveduration of drug releaseVSAvoidcontrolled release capability

Core Design Contradiction:

Duration of action of moving objectVSReliability

Solution Approach 1:

The wound care device is segmented into multiple functional layers including a base layer, functional layer containing chemical substances, and a coating film. This segmentation allows each layer to perform specific functions - the base layer provides structural support, the functional layer contains the drug reservoir, and the coating film controls the release rate, thereby achieving both extended duration and reliable controlled release

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The coating film acts as an intermediary between the functional layer containing chemical substances and the wound. It mediates the release process by controlling the diffusion rate of drugs through its specific thickness and material properties (metal oxides like aluminium oxide, titanium oxide, or silicon oxide), enabling both extended duration and controlled release capability

Inventive Principle:

Principle #24Intermediary (Mediator)

2Adaptability or versatility

If dynamic modification of drug release rate is required, then multiple functional layers are needed, but device complexity increases

Engineering Contradiction:

Improvedynamically modified release rateVSAvoidnumber of functional layers

Core Design Contradiction:

Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The device incorporates a sensor system that dynamically monitors wound conditions (such as pH, temperature, or presence of infection markers) and automatically adjusts the drug release rate through feedback control. This dynamic adaptation is achieved by integrating sensors with the coating film, allowing the system to respond to changing wound phases without requiring manual intervention or complex multi-chamber structures

Inventive Principle:

Principle #15Dynamics

Solution Approach 2:

A feedback control mechanism is implemented where sensors detect wound condition parameters and this information is used to modulate the drug release rate from the functional layer. The feedback loop enables the system to adapt to different phases of wound repair (inflammatory, proliferative, remodeling) by adjusting release rates accordingly, achieving versatility without proportionally increasing structural complexity

Inventive Principle:

Principle #23Feedback

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The solution allows for prolonged, efficient wound healing with reduced antibiotic resistance, enabling smart, cost-effective wound care devices that monitor and manage wound conditions, promoting sterility and controlled medicine release.

Implementation Method 1

the coating film is configured to dissolve and release the chemical substance(s) contained in the functional layer to skin through the skin-contact surface

Methodology Applied

Scientific EffectDissolution:

Implementation Method 2

The coating film is established from a number of coating layers deposited with a method of chemical deposition in gaseous (vapour) phase, such as atomic layer deposition (ALD)

Methodology Applied

Scientific EffectAtomic layer deposition: Physical Vapour Deposition

Implementation Method 3

detecting, from skin, of at least one predetermined condition selected from temperature, moisture, ionic content

Methodology Applied

Scientific EffectTemperature detection:

Implementation Method 4

detecting, from skin, of at least one predetermined condition selected from temperature, moisture, ionic content

Methodology Applied

Scientific EffectMoisture detection:

Data Source

PatentEP3714908B1A device for wound care, method to manufacture and uses thereof

Publication Date: 2024.03.06 PICOSUN OY

Figure 1
Figure 2A~2B

AI summary

A device for wound care, related method of manufacturing and uses are provided. The device 100 comprises a base layer 10, a functional layer 20 supported on the base layer and containing at least one chemical substance 21 suitable for wound care and a coating film 22 laid over said functional layer and having a skin-contact surface 22A. The coating film 22 is configured, upon being contacted with skin, to dissolve and to release said chemical substance 21 to skin through the skin-contact surface 22A. The coating film 22 is preferably an atomic layer deposition (ALD) film.