Aldol-Crosslinked Hydrogel Adhesive for Tissue Sealing
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Solution Overview
Problem
Conventional tissue adhesives face limitations such as toxicity, poor mechanical strength, and inadequate adhesion to biological tissues, along with issues like rapid curing or dissolution, making them unsuitable for various medical applications.
Innovation Solution
A polymer tissue adhesive formed by reacting an oxidized polysaccharide with a poly(hydroxylic) compound derivatized with acetoacetate groups in the presence of a base catalyst, which provides a biocompatible, strong, and stable adhesive with adjustable cure time.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional hydrogel adhesives are used, then adhesion and cohesion properties are improved, but the hydrogels swell or dissolve too quickly and lack sufficient mechanical strength
Solution Approach 1:
The patent creates a composite hydrogel system by crosslinking oxidized polysaccharide chains with poly(hydroxylic) compounds derivatized with acetoacetate groups. This composite structure combines the biocompatibility and adhesion of polysaccharides with the mechanical strength and stability of the crosslinked poly(hydroxylic) network, resolving the contradiction between good adhesion/cohesion and sufficient mechanical strength.
Solution Approach 2:
The patent modifies the chemical parameters of the adhesive components by oxidizing polysaccharides to introduce reactive aldehyde groups and derivatizing poly(hydroxylic) compounds with acetoacetate groups. These parameter changes enable controlled crosslinking that enhances mechanical strength while maintaining adhesion properties, and allows tuning of cure time through base catalyst concentration.
2Reliability
If polyamines are used at high concentrations to improve adhesion, then adhesive properties are enhanced, but biocompatibility is reduced
Solution Approach 1:
The patent changes the chemical nature of the adhesive components by using oxidized polysaccharides and poly(hydroxylic) compounds derivatized with acetoacetate groups instead of high-concentration polyamines. This parameter change maintains effective adhesion through covalent crosslinking while improving biocompatibility by eliminating the need for high polyamine concentrations that are toxic to some tissues.
3Productivity
If fast-curing hydrogels are used, then productivity is improved, but adaptability to different applications is reduced
Solution Approach 1:
The patent introduces dynamic control over the curing process by using base catalysts whose concentration can be adjusted to achieve different cure rates. This dynamic parameter allows the same adhesive system to be adapted to various applications requiring different cure times, from rapid sealing to controlled bonding, thereby resolving the contradiction between fast curing and application versatility.
Solution Approach 2:
The patent enables parameter adjustment of cure time by varying the concentration of base catalyst in the adhesive formulation. This parameter change allows tailoring of the curing speed to match specific application requirements, providing adaptability across different medical procedures while maintaining the core adhesive performance.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The resulting adhesive exhibits good adhesion, cohesion, mechanical strength, and stability, while being non-toxic and non-inflammatory, allowing for tailored cure times suitable for diverse medical applications.
Implementation Method 1
polymer tissue adhesive formed by reacting an oxidized polysaccharide with a poly(hydroxylic) compound derivatized with acetoacetate groups in the presence of a base catalyst
Data Source
AI summary
Methods for sealing an orifice in tissue in the body of a living animal using an adhesive formed by reacting an oxidized polysaccharide with a poly(hydroxylic) compound derivatized with acetoacetate groups in the presence of a base catalyst are disclosed. Methods for using the adhesive for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; and drug delivery are described.