Monovalent Alginate-Bone Marrow Composition for Cartilage Regeneration
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Solution Overview
Problem
Current treatments for cartilage injuries, particularly large defects, lack effective methods for repairing and regenerating hyaline cartilage due to the absence of vascular and neural networks in articular cartilage, leading to inadequate self-repair and often resulting in joint pain and osteoarthritis.
Innovation Solution
A composition combining concentrated bone marrow aspirate with a monovalent metal salt of alginic acid is applied to cartilage injuries, providing fluidity and promoting the regeneration of hyaline cartilage, which can be used to treat both cartilage and subchondral bone defects, even in large areas.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If concentrated bone marrow fluid is transplanted directly into cartilage defect, then fluidity and ease of application are improved, but adhesion and fixation at the defect site deteriorate
Solution Approach 1:
The patent introduces alginate as an intermediary carrier material that mediates between the liquid bone marrow fluid and the cartilage defect site. The alginate forms a gel matrix that provides adhesion and fixation properties, allowing the bone marrow fluid to be retained at the defect site while maintaining ease of application through injection or direct application methods.
Solution Approach 2:
The patent creates a composite treatment material combining bone marrow fluid with alginate. This composite material integrates the regenerative properties of bone marrow fluid with the adhesive and structural properties of alginate, achieving both ease of application and reliable fixation at the defect site simultaneously.
2Reliability
If biological materials are shaped and fixed to match cartilage defect, then adhesion and fixation are improved, but surgical complexity and time required deteriorate
Solution Approach 1:
The patent utilizes the gelation properties of alginate, which can transition from a liquid or semi-liquid state during application to a solid gel state after implantation. This parameter change allows the material to be easily applied in a fluid state and then automatically set in place, eliminating the need for complex shaping and fixing procedures during surgery.
3Ease of manufacture
If cartilage defects are left untreated, then surgical intervention is avoided, but joint pain and osteoarthritis progression worsen
Solution Approach 1:
The patent leverages the body's own regenerative capabilities by transplanting concentrated bone marrow fluid, which contains stem cells and growth factors, to the cartilage defect site. This self-service approach allows the patient's own biological systems to repair the cartilage damage, avoiding the need for complex surgical interventions while treating the harmful effects of untreated cartilage defects.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively repairs and regenerates hyaline cartilage, alleviates pain, reduces dysfunction, and prevents the progression of cartilage-related diseases, as demonstrated by improved macroscopic, histological, and mechanical properties in treated tissues.
Implementation Method 1
the composition has fluidity when applied to the cartilage injury lesion
Data Source
AI summary
Provided is a composition for treating cartilage injury lesion that is combined with a concentrated bone marrow aspirate and applied to a cartilage injury lesion, that has flowability when applied to the cartilage injury lesion, and that contains a monovalent metal salt of alginic acid. Thereby, a novel composition for treating cartilage injury lesion that can be used to restore and/or regenerate cartilage tissue is provided.