Biogenic Substance Detection Using Aligned Metallic Nanorods
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Solution Overview
Problem
Existing biogenic substance detection apparatuses using localized surface plasmon resonance have complex structures and low measurement accuracy due to the need for precise control of light source, detection regions, and photoreceiver positioning, making them unsuitable for reducing size and improving accuracy.
Innovation Solution
A method and apparatus utilizing metallic nanorods with aligned long axes, where polarized light is transmitted parallel to the nanorods' long axes to measure biogenic substance concentrations by rotating the polarizing plate or light source, allowing for high-accuracy detection without complex optical axis control.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If multiple detection regions with different optical properties are provided on the substrate surface, then multiple biogenic substances can be detected simultaneously, but the apparatus structure becomes complex and size reduction becomes difficult
Solution Approach 1:
The patent combines multiple detection functions into a single detection region by using metallic nanorods with different orientations (long-axis directions) rather than separate detection regions. Each nanorod orientation responds to polarized light in specific directions, allowing multiple substances to be detected simultaneously in one location without requiring multiple optical axes or complex apparatus structures.
Solution Approach 2:
The patent introduces the dimension of nanorod orientation (angular arrangement) to achieve multiple detection functions. Instead of using spatial separation (multiple detection regions), the invention uses directional orientation of nanorods to create distinct optical responses, thereby reducing apparatus complexity while maintaining versatility.
2Measurement precision
If light source, detection regions, and photoreceiver positioning is controlled with high accuracy, then measurement accuracy is improved, but the apparatus structure becomes more complex
Solution Approach 1:
The patent replaces the mechanical positioning system (precise control of light source, detection regions, and photoreceiver) with an optical polarization system. By using polarized light and the optical properties of metallic nanorods, the measurement accuracy is achieved without requiring complex mechanical alignment and positioning mechanisms.
Solution Approach 2:
The patent changes the measurement approach from spatial positioning parameters to optical polarization parameters. By controlling the polarization direction of incident light relative to the nanorod long axes, the system achieves high measurement accuracy through optical parameter control rather than mechanical position control.
3Adaptability or versatility
If multiple optical axes are provided for radiating light to different detection regions, then multiple biogenic substances can be detected, but the apparatus size increases
Solution Approach 1:
The patent merges multiple optical detection functions into a single optical path by using metallic nanorods with different orientations in one detection region. This eliminates the need for multiple optical axes and multiple light sources, thereby reducing apparatus size while maintaining the capability to detect multiple biogenic substances simultaneously.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables easy and accurate detection of multiple biogenic substances with a compact apparatus, reducing the need for precise positional control and multiple optical axes, thus improving measurement accuracy and reducing apparatus size.
Implementation Method 1
A method and apparatus for biogenic substance concentration measurement are provided, with utilization of localized surface plasmon resonance
Implementation Method 2
a polarizing plate for polarizing light radiated from the light source
Data Source
AI summary
The present invention provides an apparatus for biogenic substance concentration measurement including: a cell including therein a first region, a second region, and a test solution retention space; a light source; a polarizing plate; and a photoreceiver, in which a plurality of first metallic nanorods each having a first antibody on a surface thereof are immobilized on the first region, a plurality of second metallic nanorods each having a second antibody on a surface thereof are immobilized on the second region, the respective long axes of the plurality of first metallic nanorods are aligned in the same direction, the respective long axes of the plurality of second metallic nanorods are aligned in the same direction, the long-axis direction of the first metallic nanorod is orthogonal to the long-axis direction of the second metallic nanorod, and at least one of the polarizing plate and the cell is capable of rotation with an optical axis as the rotation axis.