Alkaline Buffered Liquid Neutralizes Chemotherapy Acid

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Solution Overview

Problem

Chemotherapy side effects, such as nausea, hair loss, and difficulty breathing, are severe and often require additional medications that have their own side effects, complicating treatment and patient health.

Innovation Solution

A buffered aqueous liquid with a pH of 10 to 11.5, composed of sodium bicarbonate, sodium carbonate, and trisodium phosphate, is administered to patients to neutralize acid and promote alkalinity, reducing chemotherapy side effects by maintaining a healthy pH balance.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Object-affected harmful factors

If additional medications are administered to treat chemotherapy side effects, then the side effects are managed, but the patient is subjected to more negative side effects from the additional drugs

Engineering Contradiction:
Improvechemotherapy side effectsVSAvoidside effects from additional medications
Core Design Contradiction:
Object-affected harmful factorsVSObject-generated harmful factors

Solution Approach 1:

The patent converts the harmful acidic environment created by chemotherapy into a beneficial condition by administering alkaline substances (pH 10-11.5) that neutralize the acid. This transforms the harmful acidic byproducts of chemotherapy into a balanced pH environment, reducing side effects without requiring additional medications that would introduce new harmful factors.

Inventive Principle:
Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The patent changes the pH parameter of the patient's body environment from acidic (harmful) to alkaline (beneficial). By administering compositions with pH 10-11.5, the patent shifts the body's pH balance to reduce chemotherapy side effects, addressing the root cause rather than treating symptoms with more drugs.

Inventive Principle:
Principle #35Parameter changes

2Object-affected harmful factors

If multiple types of drugs are administered to address different side effects, then comprehensive symptom management is achieved, but the complexity of treatment increases

Engineering Contradiction:
Improvechemotherapy side effectsVSAvoidtreatment complexity
Core Design Contradiction:
Object-affected harmful factorsVSDevice complexity

Solution Approach 1:

The patent employs a universal alkaline composition (pH 10-11.5) that addresses multiple chemotherapy side effects simultaneously through a single mechanism (pH neutralization). This multi-functional approach replaces the need for multiple specialized medications, each targeting specific side effects, thereby simplifying the overall treatment regimen while maintaining comprehensive symptom management.

Inventive Principle:
Principle #6Universality (Multi-functionality)

3Reliability

If the body's pH is maintained at 7.4, then the body's resistance to harm is enhanced, but the ability to neutralize acidic byproducts of chemotherapy is reduced

Engineering Contradiction:
Improvebody's resistance to harmVSAvoidacidic byproducts of chemotherapy
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent applies preliminary action by administering alkaline compositions (pH 10-11.5) before or during chemotherapy treatment to preemptively neutralize acidic byproducts. This preliminary alkaline intervention prevents excessive acidification, allowing the body to maintain its optimal pH 7.4 resistance state while still effectively managing chemotherapy-induced acidity.

Inventive Principle:
Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach significantly reduces chemotherapy side effects, improving patient health by maintaining a pH of 7.4, which enhances the body's resistance to harm and reduces adverse reactions to medications.

Implementation Method 1

A buffered aqueous liquid with a pH of 10 to 11.5, composed of sodium bicarbonate, sodium carbonate, and trisodium phosphate, is administered to patients to neutralize acid and promote alkalinity

Methodology Applied
Scientific EffectpH neutralization:

Data Source

PatentUS11253595B2Treatment for reducing adverse events including chemotherapy discomfort and other conditions
Publication Date: 2022.02.22 SIAMON

AI summary

This disclosure relates to treatments for reducing the side effects associated with treatment of a medication or drug, such as a chemotherapy medication, being experienced by a patient. This may be accomplished by administering to a patient taking the medication, a buffered aqueous liquid having a pH of about 10 to about 11.5, wherein the buffered aqueous liquid comprises sodium bicarbonate, sodium carbonate, and trisodium phosphate.