Alkaline Phosphatase Preserves Renal Function During Dialysis

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Solution Overview

Problem

Current treatments for acute kidney injury (AKI) often lead to reduced renal function, increased morbidity, and mortality, with renal replacement therapy (RRT) itself being stressful for the kidneys and potentially causing further kidney damage, necessitating alternative methods to preserve and enhance renal function.

Innovation Solution

Administration of alkaline phosphatase (AP) before, during, and after treatments that risk reducing renal function, such as RRT, exposure to contrast media, or nephrotoxic drugs, to prevent kidney damage and enhance renal function by improving creatinine clearance and reducing the need for RRT.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If renal replacement therapy (RRT) is administered to treat acute kidney injury, then renal function is supported and life is sustained, but the RRT itself causes stress to the kidneys and may lead to further kidney damage

Engineering Contradiction:

Improverenal function supportVSAvoidkidney damage from RRT

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

Alkaline phosphatase acts as a protective intermediary substance that mitigates the harmful effects of RRT on kidney tissue. The enzyme is administered to patients undergoing RRT to reduce oxidative stress and inflammation caused by the therapy, thereby protecting renal function while allowing necessary dialysis treatment to proceed

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

Alkaline phosphatase is administered before or during RRT to preemptively counteract the harmful effects that RRT will have on kidney tissue. This preliminary protective action reduces oxidative stress and inflammation before they can cause significant damage, allowing the RRT to be performed with minimized adverse effects

Inventive Principle:

Principle #9Preliminary anti-action

2Productivity

If contrast media or nephrotoxic drugs are administered to treat medical conditions, then the intended therapeutic effect is achieved, but renal function is reduced and kidney damage occurs

Engineering Contradiction:

Improvetherapeutic effectVSAvoidrenal function

Core Design Contradiction:

ProductivityVSReliability

Solution Approach 1:

Alkaline phosphatase is administered before exposure to contrast media or nephrotoxic drugs to establish protective mechanisms in advance. The enzyme prepares the kidney tissue by enhancing antioxidant defenses and reducing inflammation, creating a protective state that mitigates the subsequent harmful effects of the therapeutic agents

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

Alkaline phosphatase serves as a protective intermediary between the therapeutic agents (contrast media or nephrotoxic drugs) and the kidney tissue. It absorbs and neutralizes the harmful effects of these agents through its antioxidant and anti-inflammatory properties, allowing the therapeutic agents to exert their intended effect while protecting renal function

Inventive Principle:

Principle #24Intermediary (Mediator)

3Ease of operation

If conventional treatments for acute kidney injury are administered, then renal function is managed, but morbidity and mortality increase and renal function deteriorates further

Engineering Contradiction:

Improverenal function managementVSAvoidrenal function

Core Design Contradiction:

Ease of operationVSReliability

Solution Approach 1:

Alkaline phosphatase acts as a protective intermediary that enhances the effectiveness of conventional AKI treatments while reducing their harmful effects. The enzyme mitigates oxidative stress and inflammation caused by conventional therapies, thereby preserving renal function and reducing morbidity and mortality associated with standard care

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

AP effectively preserves and increases renal function, reduces the duration of RRT, and decreases the adverse effects of medications, allowing patients to receive necessary treatments with lower risks of renal function deterioration.

Implementation Method 1

Alkaline phosphatase (AP; EC 3.1.3.1), which catalyses the reaction of a phosphatase monoester and H2O to an alcohol and phosphate

Methodology Applied

Scientific EffectHydrolysis: Hydrolysis

Data Source

PatentEP3222286B1The use of alkaline phosphatase for preserving renal function

Publication Date: 2020.10.21 AM PHARMA

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AI summary

The invention relates to the field of medicine and in particular to means and methods for preserving renal function after a treatment with a risk of reducing renal function. The present invention also relates to means and methods for shortening the duration of renal replacement therapy, increasing the creatinine clearance and decreasing the adverse effects of medicaments.