Antimicrobial Composition Using Alkanediol and Glyceryl Ether Synergy

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Solution Overview

Problem

Existing antimicrobial agents used in cosmetics often exhibit insufficient antimicrobial activity and require high concentrations, posing challenges in safety and efficacy.

Innovation Solution

A combination of 1,2-alkanediols and monoalkyl glyceryl ethers with specific alkyl group lengths, along with tripropylene glycol, 2-methyl-1,3-propanediol, or 3-methyl-1,3-butanediol, to enhance antimicrobial performance while maintaining skin safety.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If diol compounds and their mixtures are used as antimicrobial agents, then safety for the human body is improved, but antimicrobial activity is insufficient

Engineering Contradiction:

Improvesafety for the human bodyVSAvoidantimicrobial activity

Core Design Contradiction:

ReliabilityVSQuantity of substance

Solution Approach 1:

The patent combines 1,2-alkanediol (component A) with tripropylene glycol (component B) to create a synergistic antimicrobial composition. This merging of two compatible substances produces enhanced antimicrobial activity that neither component achieves alone, while maintaining high safety profiles for human body use.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The invention creates a composite antimicrobial system by formulating specific combinations of 1,2-alkanediol and tripropylene glycol. This composite approach allows the composition to achieve both high safety and high antimicrobial activity, resolving the contradiction between these two properties.

Inventive Principle:

Principle #40Composite materials

2Quantity of substance

If conventional antimicrobial agents are used to achieve high antimicrobial activity, then antimicrobial performance is improved, but skin irritancy increases

Engineering Contradiction:

Improveantimicrobial activityVSAvoidskin irritancy

Core Design Contradiction:

Quantity of substanceVSObject-affected harmful factors

Solution Approach 1:

The patent changes the chemical parameters by selecting specific 1,2-alkanediols with 6-8 carbon atoms and specific tripropylene glycol structures. This parameter optimization allows the composition to achieve high antimicrobial activity while maintaining low skin irritancy, as these specific parameters balance efficacy and safety.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

Tripropylene glycol acts as an intermediary substance that enhances the antimicrobial activity of 1,2-alkanediol without introducing the skin irritancy associated with conventional antimicrobial agents. This intermediary approach allows achievement of high antimicrobial performance while avoiding harmful effects on skin.

Inventive Principle:

Principle #24Intermediary (Mediator)

Data Source

PatentUS11260003B2Antimicrobial composition and cosmetic containing antimicrobial composition

Publication Date: 2022.03.01 ADEKA CORP

AI summary

An antimicrobial composition containing: a component (A) that is at least one selected from the group consisting of 1,2-alkanediols having an alkyl group having 6 to 8 carbons and monoalkyl glyceryl ethers having an alkyl group having 6 to 8 carbons; and a component (B) that is at least one selected from the group consisting of tripropylene glycol, 2-methyl-1,3-propanediol, and 3-methyl-1,3-butanediol and a cosmetic containing the antimicrobial composition.