Alkoxy Heteroaryl Carboxamides for Selective Insect Control

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Solution Overview

Problem

Existing pesticidal compounds are inadequate in effectively controlling animal pests, particularly insects, due to limitations in efficacy and specificity.

Innovation Solution

Development of novel alkoxy heteroaryl-carboxamide and thioamide compounds, including substituted pyridinyl, pyrazinyl, and pyridazinyl derivatives, which exhibit potent pesticidal activity against arthropods and insects.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If existing pesticidal compounds are used, then pest control is provided, but efficacy and specificity are insufficient

Engineering Contradiction:

Improvepest control efficacyVSAvoidspecificity against animal pests

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent applies parameter changes by modifying the chemical structure of pesticidal compounds through systematic variation of substituents at specific positions (R1-R10) on the heteroaryl-carboxamide core structure. This includes changing alkyl chain lengths, halogen types and positions, cycloalkyl groups, and heteroaryl moieties to optimize both efficacy against pests and specificity for target species while maintaining acceptable environmental profiles

Inventive Principle:

Principle #35Parameter changes

2Adaptability or versatility

If broad spectrum pesticidal activity is achieved, then pest control coverage is improved, but environmental impact may increase

Engineering Contradiction:

Improvebroad spectrum activityVSAvoidenvironmental impact

Core Design Contradiction:

Adaptability or versatilityVSObject-affected harmful factors

Solution Approach 1:

The patent applies local quality by designing compounds with specific substituent patterns that confer selective toxicity toward pest species while sparing non-target organisms. By carefully selecting and positioning functional groups (such as fluoroalkyl, cycloalkyl, and heteroaryl substituents) at specific locations on the molecular structure, the compounds achieve broad spectrum activity against arthropods and insects while maintaining reduced environmental impact through improved selectivity and reduced persistence in non-target ecosystems

Inventive Principle:

Principle #3Local quality

Data Source

PatentUS20260015325A1Alkoxy heteroaryl- carboxamide or thioamide compounds

Publication Date: 2026.01.15 SYNGENTA CROP PROTECITON AG

AI summary

Compounds of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides.