Alkyl Ether Derivative for Nerve Injury Rehabilitation

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Solution Overview

Problem

Conventional rehabilitation methods for nerve injuries, such as stroke or spinal cord injuries, have limited effectiveness in recovering functional disorders, leading to incomplete recovery and societal reintegration for many patients.

Innovation Solution

An alkyl ether derivative represented by the general formula, or its salt, with specific functional groups and substitutions, is used to enhance the rehabilitation effect by promoting neuroprotection, neuroregeneration, and neurogenesis, thereby improving recovery rates and functional recovery in nerve injury patients.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional rehabilitation methods are used for nerve injury recovery, then basic rehabilitation procedures can be provided, but the recovery effect from functional disorders is insufficient and many patients cannot return to society

Engineering Contradiction:
Improverecovery effectVSAvoidreturn to society rate
Core Design Contradiction:
ReliabilityVSProductivity

Solution Approach 1:

The patent applies parameter changes by introducing a specific chemical compound (alkyl ether derivative with formula (1)) that modifies the biological parameters of nerve tissue recovery. The compound changes the chemical composition parameter by providing neuroprotective and neuroregenerative effects, thereby improving the reliability of recovery and enabling patients to return to society

Inventive Principle:
Principle #35Parameter changes

2Reliability

If rehabilitation is performed after nerve injury, then functional disorder recovery is attempted, but the effect is limited and disorders often remain

Engineering Contradiction:
Improvefunctional disorder recoveryVSAvoidrehabilitation system
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent introduces an intermediary substance (alkyl ether derivative) that mediates between the rehabilitation process and the nerve tissue recovery. This compound acts as a biological mediator that enhances neuroprotection, neuroregeneration, and neurite outgrowth, thereby improving functional disorder recovery without adding complexity to the rehabilitation system itself

Inventive Principle:
Principle #24Intermediary (Mediator)

Data Source

PatentEP3100725B1Post nerve injury rehabilitation effect-enhancing agent comprising an alkyl ether derivative or a salt thereof
Publication Date: 2020.05.06 FUJIFILM TOYAMA CHEMICAL CO LTD
  • EP3100725B1 patent drawingFigure 1~2
  • EP3100725B1 patent drawingFigure 3~4
  • EP3100725B1 patent drawingFigure 5~7

AI summary

Provided is a medicinal composition characterized by comprising an alkyl ether derivative represented by general formula [1] [wherein: R1 and R2 are the same or different and represent a hydrogen atom, a halogen atom, an optionally substituted C1-6 alkyl group, an optionally substituted aryl group, etc.; R3 represents an optionally protected hydroxyl group, etc.; and m and n are the same or different and represent an integer of 1 to 6] or a salt thereof. The medicinal composition according to the present invention is useful as a post nerve injury rehabilitation effect-enhancing agent.