Alkyl Ketal Ester Antimicrobial Composition for Broad-Spectrum Protection
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Solution Overview
Problem
There is a need for antimicrobial agents that are toxicologically acceptable, well-tolerated by the skin, stable in cosmetic and pharmaceutical formulations, substantially odorless, and of natural origin, with broad-spectrum activity against various microorganisms, particularly Candida and Aspergillus, and effective across different pH values, while minimizing the use of biocides and sterilization due to their undesirable effects.
Innovation Solution
A synergistic composition comprising an effective amount of an alkyl ketal ester compound, such as ethyl propylene glycol acetal levulinate or ethyl glycerine acetal levulinate, combined with an antimicrobial agent, demonstrating enhanced antimicrobial efficacy against bacteria, yeast, and fungi, including species like Staphylococcus, Candida, Aspergillus, and Pseudomonas.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional antimicrobial agents (e.g., parabens, benzoic acid) are used to prevent microbial growth, then microbial contamination is reduced, but toxicological acceptability and skin tolerance deteriorate
Solution Approach 1:
The patent changes the chemical parameters of the antimicrobial agent by using natural essential oils (cinnamon, clove, allspice, nutmeg, ylang ylang, rose, thyme) instead of conventional synthetic preservatives. This parameter change maintains microbial protection while improving toxicological acceptability and skin tolerance, as these natural oils have been used in cosmetics for centuries and are generally well-tolerated.
Solution Approach 2:
The patent employs natural essential oils that can be easily replaced and are biodegradable, avoiding the need for persistent synthetic chemicals. These natural agents provide sufficient protection during the product shelf life without leaving harmful residues, aligning with the principle of using temporary, environmentally friendly substances.
2Object-affected harmful factors
If natural antimicrobial substances (e.g., propolis, cinnamon bark, clove oil) are used, then toxicological acceptability and natural origin are improved, but research adequacy and efficacy consistency deteriorate
Solution Approach 1:
The patent selects essential oils that demonstrate broad-spectrum antimicrobial activity against multiple types of microorganisms (bacteria, fungi, yeasts) while maintaining good toxicological profiles. These oils serve multiple functions: antimicrobial protection, skin conditioning, and aromatic properties, thereby achieving reliability through multi-functionality.
Solution Approach 2:
The patent creates composite antimicrobial formulations by combining multiple essential oils (cinnamon, clove, allspice, nutmeg, ylang ylang, rose, thyme) in specific ratios. This composite approach enhances overall efficacy and consistency by leveraging the synergistic effects of different oil components while maintaining acceptable toxicological profiles.
3Reliability
If higher concentrations of antimicrobial agents are used to ensure broad-spectrum activity, then microbial protection is improved, but product stability and odor neutrality deteriorate
Solution Approach 1:
The patent optimizes the concentration parameters of essential oils to achieve effective broad-spectrum antimicrobial activity at low to moderate concentrations. By carefully selecting and balancing the oil components, the formulation maintains product stability and odor neutrality while providing comprehensive microbial protection, avoiding the need for high concentrations that would cause instability and unwanted odors.
Data Source
AI summary
The present invention refers to a composition comprising or consisting of a synergistic combination of an effective amount of an antimicrobial agent and an effective amount of an alkyl ketal ester compound. In a further aspect the present invention relates to novel antimicrobials. Furthermore, the present invention relates to food, cosmetic or pharmaceutical preparations comprising said composition. Additionally, the present invention refers to the use of said composition or of said novel antimicrobials for suppressing or inhibiting microorganism growth in food, a cosmetic or a pharmaceutical preparation. Additionally, the present invention relates to the use of an alkyl ketal ester compound, especially ethyl propylene glycol acetal levulinate and/or ethyl glycerine acetal levulinate and/or butyl-3-(2,4-dimethyl-1,3-dioxolan-2-yl-)propanoate for boosting the efficacy of an antimicrobial agent. Finally, the present invention relates to a method for suppressing or inhibiting of microorganism growth in food, cosmetic or a pharmaceutical preparations or home care products by said composition or by said novel antimicrobials.