Allulose Tablet Composition for Direct Compression Hardness
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Solution Overview
Problem
Existing technologies are unable to produce tablets with significant amounts of allulose due to its lack of compressibility and flow properties, making it difficult to achieve satisfactory hardness and ejection forces using direct compression methods.
Innovation Solution
Allulose is purified to a purity of 90.0% and adjusted to a mean volume diameter of 45-250 µm, allowing it to act as a direct compression excipient in the presence of magnesium stearate, forming tablets with a hardness greater than 50 N and ejection force less than 1200 N.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If direct compression method is used to produce tablets with allulose, then manufacturing simplicity and cost are improved, but tablet hardness and compressibility deteriorate due to allulose's poor flow and compressibility properties
Solution Approach 1:
The patent changes the physical parameters of allulose by controlling particle size (D10: 10-50 µm, D50: 50-150 µm, D90: 150-300 µm) and purity (≥90%), which transforms allulose from an incompressible material into one suitable for direct compression while achieving adequate tablet hardness
Solution Approach 2:
The patent creates a composite powder system combining allulose with magnesium stearate (0.5-5% by weight), where the lubricant component compensates for allulose's poor compressibility and flow properties, enabling direct compression while maintaining tablet integrity
2Reliability
If allulose content in tablets is increased to provide health benefits, then therapeutic effectiveness is improved, but ejection force and manufacturing difficulty worsen due to allulose's inherent properties
Solution Approach 1:
Magnesium stearate acts as an intermediary lubricant between allulose particles and the metal die surface, reducing friction and ejection force by 50-90%, thereby enabling high allulose content (≥30% by weight) tablets to be manufactured without excessive ejection forces
Solution Approach 2:
The patent optimizes the particle size distribution parameters of allulose (D10: 10-50 µm, D50: 50-150 µm, D90: 150-300 µm) to improve flow properties and reduce interparticle friction, which directly lowers ejection force while maintaining high allulose content
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution enables the production of tablets with allulose content exceeding 30% by weight, maintaining hardness and reducing ejection forces, thus overcoming the limitations of direct compression techniques.
Implementation Method 1
the mass must remain in the compact form once the compression force is removed. Hence, the directly compressible composition should allow the obtaining of tablets of sufficient hardness
Implementation Method 2
lubricants, whose role is to enable the ejection of matrices, newly formed tablets
Data Source
Figure 1~2
Figure 3
AI summary
The present invention relates to directly compressible compositions comprising more than 30 % by weight of allulose, and to tablets obtainable thereof.