Aloe Vera Cannabinoid Carrier Composition for Oral Bioavailability

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Existing cannabinoid formulations face challenges with insolubility, leading to low bioavailability, instability, and safety concerns, particularly in oral administration, and fail to effectively deliver therapeutic doses due to inconsistent and delayed uptake.

Innovation Solution

Utilizing aloe vera extract as a natural carrier and solubilizing agent to enhance the pharmacokinetic properties and bioavailability of cannabinoids, terpenes, and other volatile compounds, forming cannabinoid-infused aloe vera compositions for oral administration.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If traditional cannabinoid formulations are used for oral administration, then the compounds can be delivered systemically, but they exhibit low bioavailability due to insolubility and inconsistent uptake

Engineering Contradiction:

ImprovebioavailabilityVSAvoidconsistency of uptake

Core Design Contradiction:

Quantity of substanceVSReliability

Solution Approach 1:

The patent employs aloe vera extract as an intermediary carrier substance that mediates between the lipophilic cannabinoid compounds and the aqueous gastrointestinal environment. The aloe vera gel facilitates solubilization and enhances absorption, acting as a bridge that improves both bioavailability and consistency of cannabinoid delivery without requiring the compounds to directly interact with incompatible media

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The formulation creates a composite material system combining cannabinoids with aloe vera extract, leveraging the complementary properties of both components. The aloe vera provides hydrophilic characteristics and absorption-enhancing properties while the cannabinoids provide therapeutic activity, resulting in a composite formulation that overcomes the limitations of pure cannabinoid formulations

Inventive Principle:

Principle #40Composite materials

2Speed

If cannabinoids are administered orally without specialized carriers, then the formulation is simple, but they exhibit instability and delayed absorption

Engineering Contradiction:

Improveabsorption rateVSAvoidformulation stability

Core Design Contradiction:

SpeedVSStability of the object's composition

Solution Approach 1:

Aloe vera extract serves as a protective intermediary that stabilizes cannabinoid compounds during gastrointestinal transit. The complex matrix of aloe vera polysaccharides and bioactive compounds protects cannabinoids from degradation while simultaneously facilitating rapid absorption, resolving the contradiction between stability and absorption speed

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The aloe vera extract is prepared in advance as a stabilized carrier medium that pre-facilitates absorption pathways. By having the carrier ready and optimized before cannabinoid administration, the system eliminates delays associated with in vivo solubilization and creates immediate absorption conditions, achieving both stability and rapid uptake

Inventive Principle:

Principle #10Preliminary action

3Quantity of substance

If conventional cannabinoid delivery systems are used, then the administration method is straightforward, but they fail to provide consistent therapeutic doses

Engineering Contradiction:

Improvetherapeutic dose deliveryVSAvoiddose consistency

Core Design Contradiction:

Quantity of substanceVSReliability

Solution Approach 1:

The aloe vera-cannabinoid formulation system provides inherent feedback mechanisms through the synergistic interaction between aloe vera bioactive compounds and cannabinoids. This interaction creates a self-regulating absorption process that optimizes therapeutic dose delivery by enhancing bioavailability and maintaining consistent uptake rates, ensuring reliable therapeutic effects

Inventive Principle:

Principle #23Feedback

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enhances bioavailability, absorption profiles, and analgesic properties of cannabinoids, providing consistent and safe delivery with improved therapeutic effects.

Implementation Method 1

aloe vera extract as a natural carrier and solubilizing agent to enhance the pharmacokinetic properties and bioavailability of cannabinoids

Methodology Applied

Scientific EffectSolubilization: Solvation

Data Source

PatentUS12465628B2Cannabinoid carrier compositions having enhance pharmacokinetic properties and methods of use thereof

Publication Date: 2025.11.11 DESERT HARVEST INC

AI summary

Generally, the inventive technology relates to systems, methods, and compositions to formulate short-chain fatty acid phenolic compounds, such as cannabinoids, terpenes and other volatile compounds found in cannabinoid-producing plants such as Cannabis. In one embodiment, a natural or treated aloe vera extract may act as a cannabinoid-carrier and/or solubilizing agent forming one or more cannabinoid-infused aloe vera extract compositions, generally referred to herein as a composition or formulation of the invention. In one preferred aspect, the formulations and compositions of the invention may include safer and more palatable cannabinoid-delivery methods for both medicine and recreation. The formulations and compositions of the invention may further exhibit enhanced pharmacokinetic properties, such as enhanced bioavailability and increase adsorption in the gastrointestinal system.