Alpha-Adrenergic Eyelid Composition for Non-Surgical Ptosis Correction
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Solution Overview
Problem
Blepharoplasty, a surgical procedure for correcting ptosis and improving eye appearance, is expensive and inaccessible to many, while non-surgical alternatives like crutch glasses and scleral contact lenses are cumbersome and inadequate for cosmetic improvements.
Innovation Solution
Development of an eyeshadow composition containing alpha-adrenergic agents that stimulate Müller's muscle, formulated with dermatologically acceptable carriers and permeation enhancers, providing non-surgical alternatives for treating ptosis and enhancing eyelid separation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If blepharoplasty surgery is performed to correct ptosis and improve eye appearance, then therapeutic and cosmetic effects are achieved, but the procedure is expensive and inaccessible to many individuals
Solution Approach 1:
The patent replaces the mechanical surgical intervention (blepharoplasty) with a chemical/biological solution (topical alpha-adrenergic agent composition). The composition uses pharmacological agents to stimulate Müller's muscle and achieve ptosis correction without requiring surgical procedures, thereby making the treatment more accessible and less invasive while maintaining therapeutic effectiveness
2Ease of manufacture
If non-surgical alternatives like crutch glasses or scleral contact lenses are used to support the eyelid, then surgical intervention is avoided, but the alternatives are cumbersome to wear and may not provide adequate relief
Solution Approach 1:
The patent replaces cumbersome mechanical support devices (crutch glasses, scleral contact lenses) with a topical chemical composition applied directly to the eyelid. This substitution eliminates the need for wearing external support structures while providing adequate relief through pharmacological stimulation of Müller's muscle, thereby improving convenience and comfort
Solution Approach 2:
The composition enables the eyelid to support itself by stimulating Müller's muscle to contract and provide natural eyelid support. This self-service mechanism eliminates the need for external mechanical support devices, allowing the biological system to compensate for ptosis through pharmacologically induced muscle contraction
3Ease of manufacture
If non-surgical alternatives are used to avoid surgery, then invasive procedures are avoided, but adequate cosmetic improvement is not achieved
Solution Approach 1:
The patent replaces surgical mechanical intervention with a topical chemical composition that pharmacologically stimulates Müller's muscle. This substitution achieves cosmetic improvement by enhancing eyelid separation and visual axis through drug-induced muscle contraction, providing adequate cosmetic effect without invasive procedures
Solution Approach 2:
The patent changes the physiological state of Müller's muscle through pharmacological parameter modification. By applying alpha-adrenergic agents that stimulate muscle contraction, the composition alters the muscle's functional parameters to achieve enhanced eyelid separation and cosmetic improvement without requiring surgical structural changes
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively stimulates Müller's muscle, offering a non-invasive solution for improving eyelid separation and visual axis without surgery, suitable for both therapeutic and cosmetic uses.
Implementation Method 1
an agent that stimulates Müller's muscle, and at least one cosmetic excipient. In certain embodiments of the eyeshadow composition, the agent that stimulates Müller's muscle comprises an alpha-adrenergic agent
Implementation Method 2
the permeation enhancer increases skin permeation of the alpha-adrenergic agent by about 2-fold or greater. In certain embodiments of the dermatological composition, the alpha-adrenergic permeates through the skin and septal fat pad to contact Müller's muscle
Data Source
AI summary
The disclosure provides cosmetic and therapeutic compositions of alpha-adrenergic agents. Compositions of the disclosure may be used for topical, transdermal or parenteral administration to the eye or eyelid. The compositions of the disclosure may be used cosmetically to improve the appearance of the eye or therapeutically to treat ptosis.