Alpha-Asarone Neurological Rescue in Hemorrhagic Stroke

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Solution Overview

Problem

Current treatments for hemorrhagic stroke are inadequate, with no approved drugs to effectively rescue neurological damage and improve patient prognosis.

Innovation Solution

The use of α-asarone as a compound for treating hemorrhagic stroke, which significantly ameliorates neurological impairment, reduces brain edema, improves blood-brain barrier permeability, and prevents brain tissue atrophy.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If antiepileptic drugs are administered prophylactically to prevent secondary epilepsy after hemorrhagic stroke, then the incidence of secondary epilepsy is reduced, but neurological function is damaged and side effects increase

Engineering Contradiction:

Improveprevention of secondary epilepsyVSAvoidneurological function damage and side effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent converts the harmful effect of excitatory amino acid imbalance (which causes both epilepsy and neurological damage) into a beneficial effect by using α-asarone to restore the balance between excitatory and inhibitory amino acids, thereby preventing secondary epilepsy without damaging neurological function

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The patent changes the biochemical parameter of amino acid balance by introducing α-asarone, which modifies the concentration ratio of excitatory amino acids (glutamate) to inhibitory amino acids (GABA), transforming the pathological state into a protective state without the harmful side effects of conventional antiepileptic drugs

Inventive Principle:

Principle #35Parameter changes

2Ease of operation

If conventional drug remedies are used for hemorrhagic stroke treatment, then symptomatic treatment is provided, but efficacy is poor and no neurological damage rescue is achieved

Engineering Contradiction:

Improvesymptomatic treatmentVSAvoidneurological function rescue

Core Design Contradiction:

Ease of operationVSReliability

Solution Approach 1:

The patent introduces α-asarone as an intermediary substance that acts on the complex pathological mechanisms of hemorrhagic stroke, specifically targeting the excitotoxicity pathway to rescue neurological function, thereby bridging the gap between conventional symptomatic treatment and effective neurological rescue

Inventive Principle:

Principle #24Intermediary (Mediator)

3Reliability

If surgical treatment is performed for hemorrhagic stroke, then patient survival is improved, but curative effect on neurological dysfunctions is unsatisfactory and applicable requirements are strict

Engineering Contradiction:

Improvepatient survivalVSAvoidapplicability to different patients

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent makes the treatment approach universal by developing a drug therapy that can be applied to different types of hemorrhagic stroke patients regardless of bleeding site or severity, complementing surgical treatment and expanding therapeutic options to a broader patient population

Inventive Principle:

Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

α-Asarone demonstrates a therapeutic effect on animal models of hemorrhagic stroke by improving short-term neurological function and long-term learning and memory, reducing mortality and secondary epilepsy, and showing no obvious toxic or side effects.

Implementation Method 1

α-asarone can exert antiepileptic effects by blocking Na+

Methodology Applied

Scientific EffectIon channel blocking:

Implementation Method 2

The primary brain injury refers to direct mechanical compression injury and consequent ischemic changes of surrounding brain tissue caused by hematoma and its enlargement formed by initial hemorrhage, including excessive glutamate release

Methodology Applied

Scientific EffectInhibiting excitatory amino acid release:

Implementation Method 3

improves the permeability of blood-brain barrier, and prevent or relieve the atrophy of brain tissue

Methodology Applied

Scientific EffectBlood-brain barrier permeability improvement: Permeation

Data Source

PatentEP4205734B1Alpha-asarone for use in the treatment of hemorrhagic stroke

Publication Date: 2025.05.21 CHENGDU XINRUI TAIKANG TECH CO LTD

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AI summary

The present invention provides an application of α-asarone in the preparation of a medicine for preventing or treating hemorrhagic strokes. α-asarone has the structure shown in formula I, and may significantly improve short-term neurological deficits and long-term learning and memory functions of model rats, reduce cerebral edema, improve the permeability of the blood-brain barrier, and prevent or mitigate the atrophy of brain tissue during a recovery period. α-asarone has a precise therapeutic effect on animal models of hemorrhagic stroke without obvious toxic side effects, and is expected to have great application prospects as a medicine for preventing/treating hemorrhagic strokes.