Alpha-TCP Silicate Adhesive Composition for Tissue Bonding
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Solution Overview
Problem
Existing tissue adhesives lack sufficient mechanical strength and are ineffective for adhering soft tissues, failing to withstand shear forces and lacking biocompatibility.
Innovation Solution
An aqueous composition comprising α-TCP, a silicate compound, and a phosphorylated amino acid, with the phosphorylated amino acid making up 15-90 wt % of the solid content and the silicate compound to α-TCP weight ratio ranging from 1:0.001-100, which provides improved mechanical strength and ease of handling.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If existing tissue adhesives are used, then they provide some adhesive function, but they lack sufficient mechanical strength and cannot withstand shear forces
Solution Approach 1:
The patent uses a composite material system combining α-TCP particles, silicate compound, and phosphorylated amino acid in aqueous solution. This composite formulation achieves high adhesive strength (≥20 kPa for skin, ≥1.5 MPa for bone) and shear resistance by synergistic interaction of components, resolving the contradiction between adhesive strength and reliability for soft tissue application
Solution Approach 2:
The patent optimizes specific parameters including phosphorylated amino acid concentration (15-90 wt% of solid content), silicate to α-TCP weight ratio (1:0.001-100), and particle size distribution. These parameter adjustments enable the adhesive to achieve sufficient mechanical strength while maintaining soft tissue compatibility and shear force resistance
2Strength
If cyanoacrylates are used for adhesion, then good adhesive strength is achieved, but inflammatory response occurs during degradation
Solution Approach 1:
The patent employs biodegradable α-TCP and silicate-based materials that provide temporary adhesive function during tissue healing. These materials degrade harmlessly in the body, eliminating the inflammatory response issue associated with cyanoacrylates while maintaining sufficient adhesive strength during the critical healing period
Solution Approach 2:
The patent converts the degradation process from a harmful source of inflammation (as with cyanoacrylates) into a beneficial biodegradation mechanism. The α-TCP and silicate components degrade into biocompatible products that support tissue regeneration, transforming potential harm into therapeutic benefit
3Reliability
If fibrin glues are used, then biocompatibility is improved, but adhesive strength becomes too low
Solution Approach 1:
The patent merges the biocompatibility advantage of fibrin-based materials with the mechanical strength enhancement from α-TCP and silicate compounds. The phosphorylated amino acid component facilitates bonding between the biocompatible matrix and the reinforcing particles, achieving both high adhesive strength and excellent biocompatibility simultaneously
4Strength
If adhesives are designed for high strength, then shear force resistance improves, but ease of handling and application deteriorates
Solution Approach 1:
The patent creates a dynamic material system where the adhesive transitions from a flowable, easy-to-apply state to a high-strength cured state. The aqueous formulation provides initial fluidity for easy handling and application, while the α-TCP-silicate-phosphorylated amino acid system develops high shear strength during setting and curing, resolving the contradiction between ease of operation and strength
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition achieves high shear strength, suitable for both soft and hard tissues, with adhesive strengths of at least 20 kPa for skin and 1.5 MPa for bone, while also being biocompatible and easily tailored for specific applications.
Implementation Method 1
an aqueous composition comprising an aqueous solution, a silicate compound, α-TCP and a phosphorylated amino acid
Implementation Method 2
the weight ratio of the silicate compound and a-TCP is 1:0.001-100
Data Source
AI summary
The present invention relates to an aqueous composition comprising an aqueous solution, a-TCP, a silicate compound and a phosphorylated amino acid. The composition has improved mechanical strength and is easily applied and may be used as a tissue adhesive, implant or a filler.