Alpha-Tocopherol Acetate Oral Composition to Reduce Preterm Birth Risk

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Solution Overview

Problem

Existing compositions for oral hygiene in pregnant women are not safe and effective in reducing the risk of preterm birth and associated complications.

Innovation Solution

A composition comprising an ester of vitamin E, such as alpha-tocopheryl acetate, in combination with an oily vehicle for topical application in the oral cavity, which reduces the risk of preterm birth and low birth weight.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If disinfectants and antibiotics are used to treat periodontal disease in pregnant women, then periodontal disease is effectively treated, but safety for the unborn baby is compromised

Engineering Contradiction:
Improveeffectiveness of periodontal disease treatmentVSAvoidsafety for unborn baby
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent replaces strong disinfectants and antibiotics with vitamin E ester, a safe, natural substance that provides effective periodontal treatment without compromising fetal safety. This substitution eliminates the harmful effects of conventional treatments while maintaining therapeutic effectiveness.

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The patent changes the chemical composition parameter by using vitamin E ester instead of traditional disinfectants and antibiotics. This parameter change maintains the therapeutic function of treating periodontal disease while eliminating the harmful effects on the unborn baby.

Inventive Principle:
Principle #35Parameter changes

2Ease of operation

If conventional oral hygiene compositions are used by pregnant women, then oral hygiene is maintained, but the risk of preterm birth is not reduced

Engineering Contradiction:
Improveoral hygiene maintenanceVSAvoidrisk reduction of preterm birth
Core Design Contradiction:
Ease of operationVSReliability

Solution Approach 1:

The patent creates a multi-functional composition where vitamin E ester in oily vehicle serves both as an oral hygiene agent and as a preterm birth prevention agent. This single composition simultaneously maintains oral health and reduces preterm birth risk, eliminating the need for separate interventions.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent changes the active ingredient parameter from conventional oral hygiene agents to vitamin E ester, which provides additional preterm birth prevention benefits while maintaining oral hygiene functions.

Inventive Principle:
Principle #35Parameter changes

3Reliability

If vitamin E ester composition is used by pregnant women, then preterm birth risk is reduced, but the composition must be safely formulated for oral cavity application

Engineering Contradiction:
Improvepreterm birth risk reductionVSAvoidsafe formulation for oral cavity
Core Design Contradiction:
ReliabilityVSEase of manufacture

Solution Approach 1:

The patent uses an oily vehicle as an intermediary carrier that safely delivers vitamin E ester to the oral cavity. This carrier system ensures the composition is safe for oral application while maintaining the preterm birth prevention benefits of vitamin E ester.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent changes the formulation parameter by using an oily vehicle base, which provides safe delivery of vitamin E ester to the oral cavity while maintaining stability and safety for pregnant women and their infants.

Inventive Principle:
Principle #35Parameter changes

Data Source

PatentUS12453714B2Composition comprising an ester of alpha-tocopherol for reducing the risk of preterm birth
Publication Date: 2025.10.28 HULKA SRL

AI summary

A composition for topical application to the oral cavity, for the use in pregnant women to reduce the risk of preterm birth, comprising an ester of vitamin E with a carboxylic acid of formula R—COOH, in which R is an alkyl radical having 1 to 19 carbon atoms, or an alkenyl or alkynyl radical having 2 to 19 carbon atoms, and an oily vehicle; the ester of vitamin E can be selected from vitamin E acetate, n-propionate or linoleate, preferably alpha-tocopheryl acetate.