Alternating Tangential Flow Filtration for Continuous Bioprocessing
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Solution Overview
Problem
Current tangential flow filtration systems in bioprocessing and pharmaceutical applications require multiple batch processes, extended time, and frequent maintenance to achieve desirable retentate concentration, which is inefficient and costly.
Innovation Solution
The implementation of a continuous processing system with alternating tangential flow, utilizing synchronized diaphragm pumps to reciprocate fluid across a membrane, allowing for continuous operation without the need for batch processing, and incorporating a retentate pump to manage fluid flow and concentration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If multiple batch processes are used to achieve desirable retentate concentration, then the concentration requirement is met, but the processing time is extended and productivity is reduced
Solution Approach 1:
The patent implements continuous tangential flow filtration that operates without interruption, eliminating the need for multiple batch processes. The system maintains constant fluid flow and concentration factors over extended periods, achieving both high retentate concentration and sustained productivity through uninterrupted operation
Solution Approach 2:
The system employs periodic reversal of fluid flow direction through alternating diaphragm pump operation, creating cyclic tangential flow that prevents fouling while maintaining continuous processing. This periodic action allows the system to operate continuously without cleaning interruptions
2Productivity
If extended periods of operation are used to achieve concentration, then productivity improves, but membrane fouling increases requiring cleaning or replacement
Solution Approach 1:
The system reverses fluid flow direction periodically through synchronized diaphragm pumps, creating alternating tangential flow that prevents fouling accumulation on the membrane surface. This periodic reversal maintains membrane performance over extended operational periods without requiring cleaning or replacement
Solution Approach 2:
The alternating diaphragm pump operation creates mechanical vibration and turbulence in the fluid flow, which prevents fouling materials from adhering to the membrane surface. This mechanical action keeps the membrane clean and maintains reliable performance during continuous operation
3Manufacturing precision
If multiple batch processes are implemented, then the desired concentration is achieved, but operational complexity and maintenance requirements increase
Solution Approach 1:
The system uses continuous operation with constant concentration factors, eliminating the need for multiple batch process configurations. The synchronized diaphragm pumps and continuous flow system maintain steady-state operation, reducing operational complexity while achieving desired retentate concentration
Solution Approach 2:
The alternating tangential flow system performs multiple functions simultaneously: it concentrates retentate, prevents fouling through flow reversal, and maintains continuous operation. This multi-functionality reduces the need for separate processing steps and simplifies the overall system configuration
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables efficient and continuous concentration of fluids with reduced fouling, allowing for extended operation without cleaning or replacement of membranes, and maintaining a consistent flux and concentration factor, thereby improving productivity and reducing operational costs.
Implementation Method 1
A first diaphragm (e.g., a diaphragm pump) may be at an inlet of the retentate line configured to pump fluid toward an outlet of the retentate line. A second diaphragm may be at the outlet of the retentate line configured to pump fluid toward the inlet of the retentate line.
Implementation Method 2
A membrane may be in fluid communication with the retentate line between the first diaphragm and the second diaphragm.
Implementation Method 3
The present disclosure relates to tangential flow filters, membranes, and ultrafiltration membranes
Implementation Method 4
The fluid may be reciprocated tangentially across a membrane
Implementation Method 5
reduced fouling, allowing for extended operation without cleaning or replacement of membranes
Data Source
AI summary
The present disclosure relates to tangential flow filters, membranes, and ultrafiltration membranes, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same. In an aspect, an alternating tangential flow system for continuous processing may include a feed line containing a fluid. A retentate line may be in fluid communication with the feed line. A first diaphragm may be at an inlet of the retentate line configured to pump fluid toward an outlet of the retentate line. A second diaphragm may be at the outlet of the retentate line configured to pump fluid toward the inlet of the retentate line. A membrane may be in fluid communication with the retentate line between the first diaphragm and the second diaphragm. A retentate pump may be at the retentate outlet configured to pump the fluid out of the retentate line.