Multicomponent Composition for Alzheimer's Neuroprotection
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current treatments for neurodegenerative diseases like Alzheimer's disease are ineffective, as they primarily target single pathways, failing to address the complex biological processes involved, leading to limited therapeutic success.
Innovation Solution
Development of a pharmaceutical composition comprising nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), phenethyl isothiocyanate (PEITC), and other natural compounds that modulate multiple upstream cellular pathways associated with Alzheimer's disease, protecting neurons from cell death and regulating microglia phagocytic activity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If single pathway targeting is used in current AD treatments, then treatment simplicity is maintained, but therapeutic effectiveness is limited
Solution Approach 1:
The patent combines multiple natural compounds (NAD+, NADH, PEITC, and other antioxidants) into a single pharmaceutical composition that simultaneously targets multiple upstream cellular pathways involved in AD pathology, including mitochondrial dysfunction, oxidative stress, and neuroinflammation, thereby achieving enhanced therapeutic effectiveness without requiring multiple separate treatments
Solution Approach 2:
The pharmaceutical composition is designed to perform multiple therapeutic functions simultaneously: it acts as an antioxidant, anti-inflammatory agent, and mitochondrial enhancer, making the treatment versatile and effective against the complex, multifactorial nature of Alzheimer's disease pathology
2Reliability
If multiple upstream cellular pathways are targeted with pharmaceutical composition, then therapeutic effectiveness is improved, but composition complexity increases
Solution Approach 1:
The patent segments the complex task of targeting multiple AD pathways into distinct functional components, each natural compound in the composition being responsible for specific pathway modulation (e.g., NAD+ for mitochondrial function, PEITC for anti-inflammatory effects), allowing for systematic design and optimization of the multi-component composition
3Reliability
If natural compounds are used to modulate multiple pathways, then neuroprotective effects are achieved, but development time increases
Solution Approach 1:
The patent utilizes naturally occurring compounds that have already been shown to have beneficial biological activities in other contexts, performing preliminary validation of their safety and efficacy before combining them for AD treatment, thereby reducing the need for extensive de novo testing and accelerating development
Solution Approach 2:
The patent leverages existing knowledge about the biological activities of natural compounds from previous research and clinical use in other conditions, copying proven mechanisms of action and applying them to AD treatment, which reduces development time compared to creating entirely new therapeutic mechanisms
Data Source
AI summary
This invention relates generally to neurodegenerative diseases and conditions (e.g., Alzheimer's disease) characterized with dysfunctional energetic function, unregulated microglia phagocytic activity and other related de-regulated biological functions. This invention further relates to methods and compositions for treating such neurodegenerative diseases and conditions with pharmaceutical compositions capable of protecting neurons from cell death and unregulated microglia phagocytic activity.