Amaranth Extract Nitrate Concentration for Buccal Absorption
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Solution Overview
Problem
Current methods for enhancing nitric oxide levels in the body, particularly for individuals engaging in physical activities or requiring cardiovascular benefits, are inconvenient and less effective due to the need for frequent consumption of nitrate-rich foods like leafy vegetables.
Innovation Solution
A medicinal composition derived from Amaranth extract, enriched with nitrates, L-arginine, flavonoids, and other bioactive compounds, is provided in oral dosage forms such as fast-melt tablets, lozenges, and chewing gums for convenient buccal absorption, promoting increased nitric oxide production.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If nitrate-rich foods like leafy vegetables are consumed frequently to enhance nitric oxide levels, then nitric oxide production is improved, but convenience deteriorates due to the need for frequent consumption
Solution Approach 1:
The patent extracts the active nitrate component from nitrate-rich foods like leafy vegetables and concentrates it into a medicinal composition. This extraction allows the therapeutic effect of nitrates to be delivered in a convenient, pre-dosed form without requiring frequent consumption of large volumes of vegetables, thus resolving the contradiction between reliable nitric oxide production and ease of use.
Solution Approach 2:
The patent changes the concentration parameter of nitrate from the low levels naturally present in vegetables to highly concentrated forms in the medicinal composition. This parameter change enables a small, convenient dose to deliver the same therapeutic effect that would otherwise require consuming large quantities of vegetables frequently.
2Reliability
If conventional nitrate supplementation methods are used, then nitric oxide levels can be enhanced, but effectiveness deteriorates due to inconvenient administration
Solution Approach 1:
The patent introduces buccal absorption as an intermediary mechanism between the nitrate supplement and systemic circulation. By utilizing the buccal mucosa as an absorption pathway, the composition achieves reliable nitric oxide enhancement through a convenient, non-invasive route that improves overall effectiveness compared to conventional supplementation methods.
Solution Approach 2:
The patent replaces the mechanical system of gastrointestinal digestion and absorption with direct buccal mucosal absorption. This substitution eliminates the need for complex digestive processes and first-pass metabolism, providing a more direct, reliable, and convenient pathway for nitrate to enter the bloodstream and enhance nitric oxide levels.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The Amaranth extract composition effectively enhances nitric oxide levels in blood and saliva, improves cardiovascular performance, lowers blood pressure, and increases endurance, offering a convenient alternative to dietary nitrate intake.
Implementation Method 1
provided in oral dosage forms such as fast-melt tablets, lozenges, and chewing gums for convenient buccal absorption
Data Source
AI summary
An extract of Amaranth, having enriched nitrate content, L-arginine, Flavonoids, saponins, alkaloids, carbohydrates, proteins, potassium, and with negligible amount of oxalic acid or oxalate content. The extract of Amaranth can be prepared from fresh or dried leaves and stem of Amaranth. Dosage forms of extract include fast melt tablet, lozenge, candy, chewing gum, beverage, tablet, capsule, pill, and powder. The extract of Amaranth enhances nitric oxide concentration, enhances nitrate level concentration, and enhances nitrite level in blood as well as in saliva. Administering the extract can lower blood pressure, increase physical endurance, increase swimming endurance, increase running endurance, and improve sexual performance among human beings.