Amide Compound Insecticide Overcoming Pesticide Resistance

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Solution Overview

Problem

Current agricultural and horticultural pesticides are ineffective against resistant pests and diseases, and there is a need for novel insecticides and microbicides that can also control pests on domestic animals.

Innovation Solution

Development of an amide compound represented by a specific general formula or its salt, which is effective as an insecticide and microbicide, capable of controlling a wide range of agricultural, horticultural, and animal pests, including those resistant to existing treatments.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If existing pesticides are used, then pest control is achieved, but pests and diseases resistant to existing pesticides emerge

Engineering Contradiction:
Improvepest control effectivenessVSAvoidresistance to existing pesticides
Core Design Contradiction:
ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent applies parameter changes by developing a novel chemical compound with a new molecular structure (formula I) that differs from existing pesticides. This structural parameter change creates a new mode of action that overcomes resistance to conventional pesticides, thereby restoring effective pest control against resistant strains.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The invention employs composite material principles by creating a complex amide compound with specific substituent groups (R1-R6) that work synergistically. The compound combines multiple functional groups in a specific arrangement to achieve both high efficacy against resistant pests and selective toxicity, representing a composite molecular structure designed to overcome resistance.

Inventive Principle:
Principle #40Composite materials

2Reliability

If novel insecticides are developed, then efficacy against resistant pests is improved, but the complexity of compound structure increases

Engineering Contradiction:
Improveefficacy against resistant pestsVSAvoidcompound structure complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent applies segmentation by dividing the complex molecule into distinct functional segments represented by substituent groups R1 through R6. Each substituent can be independently selected from specific chemical groups, allowing the complex structure to be systematically designed and synthesized by combining standardized molecular building blocks.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The invention demonstrates universality through the general formula (I) that encompasses multiple specific compounds. The core amide structure with variable substituents serves as a universal scaffold that can be adapted to create different insecticides and microbicides with varying spectra of activity, including efficacy against both insects and plant pathogens.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Data Source

PatentEP3070076B1Amide compounds or salts thereof, and their use as agricultural and horticultural microbicides
Publication Date: 2022.01.05 NIHON NOHYAKU CO LTD
  • EP3070076B1 patent drawing
  • EP3070076B1 patent drawing
  • EP3070076B1 patent drawing

AI summary

In crop production in the fields of agriculture, horticulture and the like, the damage caused by insect pests etc. is still immense, and insect pests resistant to existing insecticides have emerged. Under such circumstances, the development of novel agricultural and horticultural insecticides is desired. The present invention provides an amide compound represented by the general formula (I): (wherein A1, A2 and A3 each represent a nitrogen atom or a CH group, R1 represents an alkyl group, R2 and R4 each represent a haloalkyl group, R3 represents an alkyl group, and m represents 0, 1 or 2) or a salt thereof; an agricultural and horticultural insecticide and microbicide comprising the compound or a salt thereof as an active ingredient; and a method for using the insecticide and microbicide.