Biocatalytic Amide Production With Mid-Reaction pH Shift for Foam Control
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
The production of amide compounds using biocatalysts faces challenges due to foaming issues in the amide compound aqueous solution, which complicates handling and reduces the yield of amide compound-based polymers during polymerization.
Innovation Solution
Increasing the pH of the reaction solution during the hydration reaction suppresses foaming by adjusting the pH in the latter half of the reaction to be higher than the initial pH, typically within specific ranges.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If a biocatalyst is used to produce amide compound, then the reaction conditions become mild and purity increases, but the amide compound aqueous solution foams due to protein impurity
Solution Approach 1:
The invention changes the pH parameter of the reaction solution during the hydration reaction. Specifically, the pH is increased in the middle of the reaction to be higher than the initial pH, which suppresses foaming of the amide compound aqueous solution while maintaining the benefits of biocatalytic production
2Ease of manufacture
If the amide compound aqueous solution is produced by biocatalytic method, then the production cost is reduced, but the handling and transportation becomes difficult due to foaming
Solution Approach 1:
By adjusting the pH parameter during the reaction process (increasing pH in the middle of hydration reaction), the invention suppresses foaming to facilitate handling, transportation, and storage of the amide compound aqueous solution while maintaining low production cost through biocatalytic method
3Productivity
If the amide compound aqueous solution is used for polymerization, then the yield of polymer should be maximized, but the solution overflows from polymerization kettle due to foaming
Solution Approach 1:
The invention applies pH parameter change during the hydration reaction to suppress foaming of the amide compound aqueous solution, preventing overflow during polymerization and maximizing the yield of amide compound-based polymer
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method effectively reduces foaming, facilitating the handling of the amide compound aqueous solution and improving the yield of amide compound-based polymers.
Implementation Method 1
a biocatalyst having nitrile hydratase activity
Implementation Method 2
performing a hydration reaction on a nitrile compound
Data Source
AI summary
A method for producing an amide compound from a nitrile compound using a biocatalyst by producing an amide compound aqueous solution having low foamability. In the method for producing an amide compound by performing a hydration reaction on a nitrile compound in the presence of a biocatalyst having nitrile hydratase activity, the pH of a reaction solution is increased in the middle of the hydration reaction. In one example, the hydration reaction is performed in a state in which the pH of the reaction solution in the latter half of the reaction, at which a contained amount of amide compound is 40% by mass or more with respect to the total mass of the reaction solution, is set to be higher than the pH of the reaction solution in the former half of the reaction, at which the contained amount of amide compound is less than 40% by mass with respect to the total mass of the reaction solution.