Moxidectin Imidacloprid Spot-On Stabilization
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Solution Overview
Problem
Veterinary compositions containing Moxidectin and Imidacloprid have limited storage stability, requiring specific storage conditions, which complicates their handling and distribution.
Innovation Solution
Incorporating a physiologically acceptable amine base, such as triethanolamine, at low concentrations into the veterinary composition to stabilize Moxidectin against degradation, maintaining efficacy and stability without altering the desired routes of administration for both active ingredients.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If Moxidectin and Imidacloprid are combined in veterinary compositions, then broad-spectrum antiparasitic efficacy is achieved, but storage stability deteriorates requiring specific storage conditions
Solution Approach 1:
The patent introduces an intermediary substance (antioxidant, chelating agent, or buffer) into the veterinary composition to mediate between Moxidectin and Imidacloprid, preventing their direct interaction that causes degradation. This intermediary stabilizes the formulation, allowing broad-spectrum efficacy while eliminating restrictive storage conditions.
2Stability of the object's composition
If specific storage conditions are imposed on veterinary compositions, then storage stability is maintained, but handling and distribution complexity increases
Solution Approach 1:
The patent converts the potentially harmful interaction between Moxidectin and Imidacloprid into a benefit by using it to identify and add stabilizing excipients. This transforms the stability problem into a solution, creating a formulation that is inherently stable under normal storage conditions, thereby improving handling convenience while maintaining stability.
3Reliability
If Moxidectin concentration is increased in the composition, then antiparasitic potency is improved, but degradation rate increases reducing shelf life
Solution Approach 1:
The patent changes the chemical environment parameters of the formulation by adding excipients such as antioxidants, chelating agents, or buffers. These parameter changes create a protective chemical atmosphere that allows higher Moxidectin concentrations to be maintained without increased degradation, thereby extending shelf life while preserving potency.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The amine base significantly improves storage stability, allowing the composition to be stored at higher temperatures without degradation, reducing the need for special storage conditions and minimizing impurities, thus enhancing the product's shelf life and usability.
Implementation Method 1
Incorporating a physiologically acceptable amine base, such as triethanolamine, at low concentrations into the veterinary composition to stabilize Moxidectin against degradation
Data Source
AI summary
The invention relates to a stabilized veterinary composition comprising Moxidectin in combination with Imidacloprid and an amine base for cutaneous topical application (spot-on), to the use of an amine base for stabilizing Moxidectin, and to the use of an amine base for producing a veterinary composition with improved Moxidectin stability.