Purified Amine Compound Production via Halide Salt Segmentation
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
There is no known method for producing a highly pure N-indanyl carboxamide compound, which is crucial for its industrial applications due to its antifungal activity and use as an intermediate.
Innovation Solution
A method involving reacting a crude amine compound with a hydrogen halide in the presence of water and an organic solvent, followed by phase separation, precipitation, and reaction with a base to isolate a highly pure amine compound, specifically using hydrogen chloride and controlling halide ion concentrations to achieve high purity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If conventional methods are used to produce amine compound (1), then production can proceed with standard processes, but the purity of the amine compound cannot reach 97.5% or higher
Solution Approach 1:
The purification process is divided into distinct sequential steps: (A) reaction with hydrogen halide to form salt, (B) phase separation to isolate salt-containing phase, (C) concentration of the phase, and (D) reaction with base to regenerate pure amine. This segmentation allows each step to target specific impurities and achieve cumulative purification效果, ultimately reaching 97.5% or higher purity that cannot be achieved by conventional single-step methods.
Solution Approach 2:
The hydrogen halide salt of the amine compound serves as an intermediary form during purification. By converting the crude amine to its salt form, the mixture becomes separable into distinct phases where impurities remain in one phase while the salt-containing phase is isolated. This intermediary conversion enables effective separation that directly leads to high purity recovery after base treatment.
2Manufacturing precision
If multiple purification steps are implemented to achieve high purity, then amine compound purity reaches 97.5% or more, but production time and process complexity increase
Solution Approach 1:
The purification method employs continuous useful action through sequential reactions and separations without unnecessary interruptions. The hydrogen halide reaction proceeds to completion, followed immediately by phase separation, then concentration, and finally base reaction to recover the pure amine. Each step flows into the next, maximizing productivity while achieving 97.5% or higher purity, thus resolving the time-purity tradeoff.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method effectively produces a highly pure amine compound with a purity of 97.5% or more, addressing the need for industrial-scale production of N-indanyl carboxamide.
Implementation Method 1
reacting a crude amine compound with a hydrogen halide in the presence of water and an organic solvent
Implementation Method 2
phase separation, precipitation, and reaction with a base to isolate a highly pure amine compound
Implementation Method 3
reaction with a base to isolate a highly pure amine compound
Data Source
AI summary
A method for producing a purified amine compound represented by the formula (1), including: step (A) of reacting a crude form of the amine compound represented by the formula (1) with a hydrogen halide in the presence of water and an organic solvent insoluble in water; step (B) of separating a phase in which a hydrogen halide salt of the amine compound represented by the formula (1) produced in step (A) is dissolved from the other phase (es) ; step (C) of precipitating the hydrogen halide salt of the amine compound represented by the formula (1) from the phase obtained in step (B) in which the hydrogen halide salt of the amine compound represented by the formula (1) is dissolved; and step (D) of isolating the hydrogen halide salt of the amine compound represented by the formula (1) precipitated in step (C), and reacting the salt with a base.