Amino Acid Curing System for Meat Nitric Oxide Generation

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Solution Overview

Problem

Current curing methods for meat products rely on sodium nitrite, which raises health concerns due to the formation of carcinogenic nitrosamines, and no effective single replacement ingredient has been identified to maintain microbial quality, flavor, color, and shelf stability.

Innovation Solution

A method using a curing composition comprising amino acid L-arginine, sodium chloride, and sodium erythorbate, applied to pre-rigor and post-rigor meat, which activates the Nitric Oxide Synthase system to generate nitric oxide and residual nitrite, mimicking the curing effects of sodium nitrite without its drawbacks.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If sodium nitrite is used for curing meat, then microbial quality, flavor, color, and shelf stability are maintained, but health risks arise due to formation of carcinogenic nitrosamines

Engineering Contradiction:
Improvemicrobial quality and shelf stabilityVSAvoidcarcinogenic nitrosamines formation
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent extracts and eliminates sodium nitrite from the curing composition, replacing it with amino acids (L-arginine, L-citrulline, L-ornithine) that can naturally generate nitric oxide and nitrite in vivo. This removes the harmful synthetic additive while preserving the desired curing effects through natural biochemical pathways.

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The patent changes the chemical parameters of the curing system by substituting sodium nitrite with amino acid precursors. The amino acids undergo enzymatic conversion (via nitric oxide synthase) to produce nitric oxide, which then generates nitrite in the meat, achieving the same functional effects without direct nitrite addition.

Inventive Principle:
Principle #35Parameter changes

2Object-affected harmful factors

If sodium nitrite is replaced with alternative ingredients, then health concerns are reduced, but no effective single replacement ingredient has been identified to maintain all functional properties

Engineering Contradiction:
Improvesynthetic additives eliminationVSAvoidfunctional properties maintenance
Core Design Contradiction:
Object-affected harmful factorsVSReliability

Solution Approach 1:

The patent combines multiple amino acids (L-arginine, L-citrulline, L-ornithine) in a synergistic formulation. Each amino acid contributes to nitric oxide generation through different metabolic pathways, and their combination ensures reliable production of nitrite and nitric oxide to maintain microbial quality, flavor, color, and shelf stability without synthetic additives.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The patent creates a composite curing composition consisting of multiple amino acids rather than using a single replacement ingredient. This composite approach leverages the complementary biochemical pathways of different amino acids to reliably generate the necessary nitric oxide and nitrite for effective meat curing.

Inventive Principle:
Principle #40Composite materials

3Reliability

If L-arginine is used to activate Nitric Oxide Synthase system, then nitric oxide and residual nitrite are generated mimicking sodium nitrite effects, but the mechanism requires understanding of enzymatic pathways

Engineering Contradiction:
Improvecuring effects achievementVSAvoidbiochemical mechanism complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent utilizes the meat's own endogenous Nitric Oxide Synthase enzyme system to convert the added amino acids into nitric oxide and nitrite. The biochemical machinery already present in the meat performs the conversion, eliminating the need for external synthetic additives or complex external processing systems.

Inventive Principle:
Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach effectively generates nitric oxide and residual nitrite, achieving similar microbial stability, flavor, and color to traditionally cured products while reducing sodium content and eliminating the need for synthetic additives.

Implementation Method 1

activates the Nitric Oxide Synthase system to generate nitric oxide and residual nitrite

Methodology Applied
Scientific EffectNitric Oxide Synthase system activation: Enzyme

Data Source

PatentUS20230029496A1Amino acid alternative curing system
Publication Date: 2023.02.02 TEXAS A&M UNIVERSITY
  • US20230029496A1 patent drawing
  • US20230029496A1 patent drawing
  • US20230029496A1 patent drawing

AI summary

This invention is in the field of meat processing and contemplates curing compositions and methods of use thereof. The invention also contemplates methods of using the curing compositions in the processing of meat, including both pre-rigor and post-rigor meat.