Amino Acid-Halogen Kit for Peri-implantitis Prevention
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Solution Overview
Problem
Current treatments for peri-implantitis are challenging due to the rough surface and threads of dental implants, which facilitate microbial colonization and make eradication difficult, and existing solutions like sodium hypochlorite are toxic and not effective for broad-spectrum antimicrobial action.
Innovation Solution
A kit of parts comprising a first aqueous component with amino acids and a second aqueous component containing an active halogen compound, mixed to form a treatment preparation with a pH of 9 to 11.5, which reduces toxicity and forms primary halogenated amines for effective treatment and prevention of peri-implantitis without harming the dental implant surface.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If the dental implant surface is made rough with threads to increase surface area for osseointegration, then osseointegration and healing are improved, but microbial colonization increases and eradication becomes difficult
Solution Approach 1:
The patent applies preliminary action by treating the implant surface with a chemical preparation containing sodium hypochlorite and amino acids before microbial colonization can establish. This pre-treatment creates an antimicrobial environment that prevents bacteria from harboring in the rough surface crevices, addressing the microbial colonization problem while preserving the rough surface topology needed for osseointegration.
Solution Approach 2:
The chemical preparation acts as an intermediary substance that penetrates the rough surface topology and delivers antimicrobial action without removing the surface features. The amino acids in the preparation reduce surface tension and enable deep penetration into threads and crevices, allowing the sodium hypochlorite to reach and eradicate microorganisms hidden in the rough surface structure while leaving the osseointegration-promoting topology intact.
2Reliability
If sodium hypochlorite is used as an antimicrobial agent on implant surfaces, then broad-spectrum antimicrobial effect is achieved, but toxicity to surrounding tissues increases
Solution Approach 1:
The patent converts the potential harm of sodium hypochlorite toxicity into a benefit by combining it with amino acids that reduce surface tension and control the release rate. The amino acids act as protective agents that modulate the aggressiveness of sodium hypochlorite, allowing broad-spectrum antimicrobial action while reducing tissue toxicity. This transforms the harmful toxicity into a controlled, beneficial treatment effect.
Solution Approach 2:
The preparation uses a composite formulation combining sodium hypochlorite with specific amino acids (such as cysteine, glycine, or alanine). This composite approach allows the beneficial antimicrobial properties of sodium hypochlorite to be maintained while the amino acids provide protective effects that reduce toxicity to surrounding tissues. The composite material achieves both broad-spectrum antimicrobial activity and reduced harmful effects simultaneously.
3Strength
If conventional bridge techniques are used to replace missing teeth, then stability is achieved, but adjacent natural teeth must be ground down which causes damage
Solution Approach 1:
The patent applies the taking out principle by removing the need to modify adjacent natural teeth. Instead of grinding down healthy teeth to support a bridge, the solution extracts the support function entirely from natural teeth and transfers it to an artificial implant that integrates with the bone. This eliminates the harmful grinding action on adjacent teeth while maintaining the stability function through osseointegration of the implant.
Solution Approach 2:
The dental implant acts as an intermediary structure between the missing tooth root and the crown restoration. This intermediary implant integrates with the bone through osseointegration, providing stable support without requiring modification of adjacent natural teeth. The implant mediates the load transfer function that would otherwise require grinding down neighboring teeth, thereby eliminating the harmful effect while preserving stability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The treatment preparation effectively removes microorganisms, promotes osseointegration, and can be used for both treatment and prevention of peri-implantitis, with minimal impact on the implant surface, allowing for improved healing and reduced risk of adverse effects.
Implementation Method 1
The first component reduces the aggressiveness of the active halogen compound to living tissues
Implementation Method 2
The treatment with the treatment preparation utilizes the two liquid components which when combined to the treatment preparation and applied on a site of treatment such as a dental implant surface and/or lesions associated with peri-implantitis lead to a chemical reaction which is believed to result in primary halogenated amines
Implementation Method 3
The treatment preparation effectively removes microorganisms
Implementation Method 4
The dental implant comprises a part that is fused to the bone by so-called osseointegration
Data Source
AI summary
The invention relates to a kit of parts for treatment and/or prevention of peri-implantitis. The kit of parts comprises a first aqueous component comprising one or more amino acids, and a second aqueous component comprising an active halogen compound. There is also provided a treatment preparation prepared from the components and uses thereof in the prevention and/or treatment of peri-implantitis.