Amino Acid Composition for Mitochondrial Biogenesis

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Solution Overview

Problem

Current therapeutic approaches fail to effectively address mitochondrial dysfunction, which is linked to various diseases including obesity, metabolic disorders, and muscle wasting conditions, with no drugs or nutrients found to prevent or treat sarcopenia and related disorders effectively.

Innovation Solution

A composition comprising amino acids such as leucine, isoleucine, valine, threonine, lysine, citric acid, succinic acid, and malic acid, which promotes mitochondrial biogenesis and function, potentially treating obesity and related disorders by increasing energy expenditure.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional therapeutic approaches are used, then treatment of mitochondrial dysfunction-related diseases is attempted, but no effective drugs or nutrients have been found to prevent or treat sarcopenia and related disorders

Engineering Contradiction:

Improveeffectiveness of treatmentVSAvoidavailability of effective therapies

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent changes the chemical parameters by using specific amino acid ratios (leucine, isoleucine, valine, threonine, lysine) combined with organic acids (citric, succinic, malic acid) to create a composition that promotes mitochondrial biogenesis and function, thereby treating mitochondrial dysfunction-related diseases including sarcopenia

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention creates a composite nutritional composition combining multiple amino acids and organic acids that work synergistically to enhance mitochondrial function, addressing the lack of effective single-ingredient treatments for mitochondrial dysfunction-related disorders

Inventive Principle:

Principle #40Composite materials

2Use of energy by moving object

If physical exercise is used to increase energy expenditure, then energy expenditure increases, but this is not a simple task especially for obese individuals which often show obesity-associated muscle dysfunction

Engineering Contradiction:

Improveenergy expenditureVSAvoidease of performing exercise

Core Design Contradiction:

Use of energy by moving objectVSEase of operation

Solution Approach 1:

The amino acid composition acts as an intermediary substance that enhances mitochondrial function and energy metabolism, providing a pharmacological alternative that achieves energy expenditure improvement without requiring physical exercise, thus bypassing the limitation of muscle dysfunction in obese individuals

Inventive Principle:

Principle #24Intermediary (Mediator)

3Reliability

If mitochondrial function is improved through amino acid composition, then mitochondrial biogenesis and function are enhanced, but this requires a specific combination of amino acids and organic acids

Engineering Contradiction:

Improvemitochondrial functionVSAvoidcomposition complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent optimizes the compositional parameters by specifying precise ratios of amino acids (leucine, isoleucine, valine, threonine, lysine) and organic acids (citric, succinic, malic acid) to achieve effective mitochondrial biogenesis while maintaining a manageable formulation complexity

Inventive Principle:

Principle #35Parameter changes

Data Source

PatentUS11452702B2Compositions comprising amino acids for use in the treatment of mitochondrial dysfunction-related diseases

Publication Date: 2022.09.27 PROFESSIONAL DIETETICS SPA

AI summary

Composition for promoting mitochondrial biogenesis and improving mitochondrial function in a subject, the composition comprising an active agent, said active agent containing the amino acids leucine, isoleucine, valine, threonine, lysine and citric acid, succinic acid, malic acid.