Amino Acid Nitrate Compositions for Lower-Dose Bioabsorption

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Solution Overview

Problem

Conventional amino acids, nitrates, and nitrites lack properties such as rapid vasodilation, require high doses for effectiveness, and have limited bioavailability due to insolubility, which hampers their efficiency in enhancing athletic performance and bioabsorption in humans.

Innovation Solution

Development of amino acid compositions comprising Carnitine, Taurine, and Nitrate compounds or compositions, including derivatives like acetyl-L-Carnitine and propionyl-L-carnitine, which are synthesized by combining amino acids with nitric or nitrous acid to form nitrate or nitrite salts, enhancing vasodilative characteristics and bioavailability.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional amino acids, nitrates, and nitrites are used alone, then their individual properties are maintained, but they lack rapid vasodilation, require high doses, and have limited bioavailability

Engineering Contradiction:

Improvevasodilative characteristicsVSAvoiddose requirement

Core Design Contradiction:

ReliabilityVSQuantity of substance

Solution Approach 1:

The patent combines amino acids (carnitine, taurine) with nitrates or nitrites to form composite compositions. This merging creates synergistic effects where the combination produces rapid vasodilation at lower doses than conventional single-substance approaches, directly resolving the contradiction between effectiveness and dose requirement

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The invention creates composite material formulations containing multiple amino acid-nitrate/nitrite combinations. These composite compositions leverage the complementary properties of different amino acids and nitrogen compounds to achieve enhanced vasodilative characteristics with improved bioavailability, reducing the quantity of substance needed compared to conventional single-substance treatments

Inventive Principle:

Principle #40Composite materials

2Reliability

If conventional amino acids, nitrates, and nitrites are used alone, then their individual properties are maintained, but they have limited bioavailability due to insolubility

Engineering Contradiction:

ImprovebioavailabilityVSAvoidcomposition structure

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent develops composite material formulations that combine multiple amino acids with nitrates and nitrites in specific ratios. These composite compositions improve bioavailability by enhancing solubility and absorption characteristics compared to single-substance conventional treatments, while the complexity is managed through standardized formulation protocols

Inventive Principle:

Principle #40Composite materials

3Speed

If conventional amino acids, nitrates, and nitrites are used alone, then their individual properties are maintained, but they lack rapid vasodilation

Engineering Contradiction:

Improvevasodilation rateVSAvoidcompositional flexibility

Core Design Contradiction:

SpeedVSAdaptability or versatility

Solution Approach 1:

The patent merges amino acids with nitrates and nitrites to create compositions that produce rapid vasodilation. The synergistic interaction between the combined substances accelerates the vasodilative response compared to conventional single-substance approaches, while the formulation can be adapted to include different amino acid combinations based on specific therapeutic needs

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The invention employs dynamic formulations where the ratios and combinations of amino acids, nitrates, and nitrites can be adjusted to optimize vasodilation rate for different applications. This dynamic approach allows the composition to be tailored for rapid vasodilation when needed while maintaining compositional flexibility for different therapeutic scenarios

Inventive Principle:

Principle #15Dynamics

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The compositions provide rapid vasodilation and improved bioabsorption, requiring lower doses and improving athletic performance and bioavailability, addressing the limitations of conventional amino acids and nitrates.

Implementation Method 1

increasing the vasodilative characteristics in a human

Methodology Applied

Scientific EffectVasodilation:

Implementation Method 2

increasing the bioabsorption of the compound in a human

Methodology Applied

Scientific EffectBioabsorption: Absorption (physical)

Data Source

PatentUS12522568B2Amino acid compositions

Publication Date: 2026.01.13 THERMOLIFE INTERNATIONAL LLC

AI summary

Solid supplement compositions are disclosed comprising at least one non-ester nitrate compound and at least one isolated amino acid compound. The at least one isolated amino acid compound is a separate compound than the at least one non-ester nitrate compound. The composition contains at least about 0.05625 mg nitrate ion (NO3−).