Amino Acid-Nitrate Compositions for Vasodilation and Bioavailability
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Solution Overview
Problem
Conventional amino acids, nitrates, and nitrites have limitations in terms of bioavailability, solubility, and effectiveness in achieving vasodilation and bioabsorption, requiring high doses and long metabolism times, and are prone to tolerance development.
Innovation Solution
Amino acid compositions combining specific amino acids like Arginine, Citrulline, Creatine, Glutamine, and others with nitrates or nitrites, enhancing water solubility and bioabsorption, and providing faster vasodilation effects through nitric oxide production, while preventing tolerance development.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If conventional amino acids, nitrates, and nitrites are used alone, then the formulation is simple, but bioavailability and solubility are limited requiring high doses
Solution Approach 1:
The patent combines amino acids (such as arginine, citrulline, creatine, glutamine, lysine, ornithine, proline, or valine) with nitrates or nitrites in specific formulations. This merging creates a synergistic effect where the amino acid component enhances the solubility and bioavailability of the nitrate/nitrite, allowing lower doses to achieve the same therapeutic effect while improving nitrogen oxide production and vasodilation efficiency.
2Reliability
If conventional nitrates and nitrites are used, then the formulation is straightforward, but vasodilation effectiveness is reduced and tolerance develops
Solution Approach 1:
The patent modifies the chemical and physiological parameters by combining nitrates/nitrites with specific amino acids that have complementary metabolic pathways. The amino acids serve as precursors or cofactors that enhance nitric oxide synthesis, thereby improving vasodilation effectiveness. Additionally, this parameter change prevents tolerance development by providing alternative metabolic routes and sustaining nitrogen oxide production over time.
3Reliability
If high doses of conventional nitrates are administered, then vasodilation effect is achieved, but tolerance develops rapidly
Solution Approach 1:
The patent employs preliminary action by including amino acids that serve as precursors for nitric oxide synthesis alongside nitrates or nitrites. These amino acids (such as arginine, citrulline, or ornithine) are metabolized to produce nitric oxide through alternative pathways, ensuring sustained vasodilation effectiveness. This preliminary preparation of multiple metabolic routes prevents tolerance development by maintaining nitrogen oxide production without requiring increasing doses.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The amino acid-nitrate/nitrite compositions improve bioavailability, reduce required doses, enhance vasodilation and muscle distribution, and prevent nitrate tolerance, offering sustained nitric oxide production and improved athletic performance.
Implementation Method 1
providing faster vasodilation effects through nitric oxide production
Data Source
AI summary
An amino acid composition is disclosed. The composition includes: at least one constituent selected from the group consisting of a nitrate, a nitrite, and both; and at least one constituent amino acid selected from the group consisting of Arginine, Agmatine, Beta Alanine, Citrulline, Creatine, Glutamine, L-Histidine, Isoleucine, Leucine, Norvaline, Ornithine, Valine, Aspartic Acid, Cysteine, Glycine, Lysine, Methionine, Proline, Tyrosine, and Phenylalanine. Also disclosed are a method for increasing the bioabsorption of Amino Acids in a human or animal and a method for increasing vasodilative characteristics of Amino Acids in a human or animal.