Topical Amino Acid Nutrient Composition for Local Lesion Treatment
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Solution Overview
Problem
Current treatments for local lesion diseases, such as solid tumors, face challenges in specificity and efficacy due to systemic toxicity and poor penetration of drugs into tumor tissues, especially in tumors with poor blood supply like pancreatic cancer.
Innovation Solution
A topical pharmaceutical composition containing a high-concentration amino acid based nutrient (≥2.5% to 25% w/v) combined with a synergist, such as a conventional ineffective compound or an anti-tumor chemotherapeutic agent, and a pharmaceutically acceptable liquid carrier, is administered locally to target the lesion disease.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If cytotoxic drugs are administered systemically to target tumor cells, then tumor cell suppression is achieved, but systemic toxicity increases and the difference between effective dose and safety limit becomes small
Solution Approach 1:
The invention divides the treatment approach into local injection at the tumor site rather than systemic administration. The pharmaceutical composition is segmented and delivered directly to the target lesion, achieving localized high concentration of active ingredients while avoiding widespread distribution to normal tissues, thus reducing systemic toxicity while maintaining tumor cell suppression efficacy
Solution Approach 2:
The invention applies local quality by creating a high-concentration pharmaceutical composition specifically for local injection at the tumor site. The composition contains high concentrations of amino acid-based nutrients (≥2.5% w/v) and synergists that are locally active, providing targeted therapeutic effect at the lesion site while minimizing exposure and toxicity to systemic circulation
2Quantity of substance
If topical administration of cytotoxic drugs is used to increase intratumoral concentration, then local drug concentration is improved, but significant improvement in efficacy is not achieved and non-specific tissue destruction occurs
Solution Approach 1:
The invention changes the concentration parameter of amino acid-based nutrients to high levels (≥2.5% w/v, preferably ≥5% w/v, more preferably ≥10% w/v) in the pharmaceutical composition. This parameter change enables the composition to provide both high local concentration for effective treatment and high local safety by being non-destructive to surrounding normal tissues, unlike conventional cytotoxic drugs
Solution Approach 2:
The invention uses a composite pharmaceutical composition containing multiple components: amino acid-based nutrients (≥2.5% w/v), synergists (such as conventional ineffective compounds or anti-tumor chemotherapeutic agents), and pharmaceutically acceptable liquid carriers. This composite formulation achieves synergistic effects that enhance targeting efficacy while maintaining high local safety
3Reliability
If chemical ablation agents are used to achieve high local curative effects, then local efficacy is improved, but specificity is lost and intervention volume and sites are limited
Solution Approach 1:
The invention changes the chemical nature and concentration parameters of the pharmaceutical composition to use high-concentration amino acid-based nutrients (≥2.5% w/v) combined with synergists. This parameter change enables the composition to achieve high local curative effects through synergistic action while maintaining high local safety and avoiding the strong destructive effects and limited applicability of chemical ablation agents like high-purity ethanol or high-concentration acid and base
Data Source
AI summary
The present application relates to use of amino acid based nutrients and pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition comprising a high concentration of amino acid based nutrient and a synergist thereof, an apparatus including said composition, a use of said composition in preparing a pharmaceutical composition which treats topical lesion diseases, and a method for treating the local lesion diseases.