Amino Group-Modified Adsorption Material for TGF-β
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Solution Overview
Problem
Existing adsorption materials struggle to efficiently adsorb Transforming Growth Factor-β (TGF-β) and LAP-bound TGF-β while maintaining the physical strength of the carrier material, as high hydrophilicity can hinder adsorption efficiency and physical strength.
Innovation Solution
A water-insoluble carrier with a nitrogen-containing compound, such as a polyamine or aliphatic amine, is used, with specific ranges of amino group content to ensure efficient adsorption of TGF-β or LAP-bound TGF-β while retaining physical strength, including a total content of amino groups between 0 and 2500 μmol per 1 g and a primary amino group content of 450 μmol or less per 1 g.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a quaternary ammonium group or hydrophilic amine residue is immobilized to a water-insoluble carrier to adsorb LAP-bound TGF-β, then adsorption capability is improved, but physical strength of the carrier material deteriorates
Solution Approach 1:
The patent changes the chemical parameters of the amino groups by selecting specific types (primary, secondary, or tertiary aliphatic amino groups) and controlling their content ratios. This parameter optimization allows achieving effective TGF-β adsorption while maintaining carrier physical strength, resolving the contradiction between adsorption capability and physical strength.
Solution Approach 2:
The patent creates a composite adsorption material combining a water-insoluble carrier with specifically selected amino group compounds. The composite structure integrates the mechanical strength of the water-insoluble carrier with the targeted adsorption capability of the aliphatic amino groups, achieving both requirements simultaneously.
2Productivity
If high hydrophilicity is introduced to enhance adsorption efficiency, then adsorption efficiency is improved, but physical strength of the carrier material deteriorates
Solution Approach 1:
The patent optimizes the hydrophilicity parameter by selecting aliphatic amino groups with specific structural characteristics (primary, secondary, or tertiary) rather than using highly hydrophilic quaternary ammonium groups. This parameter adjustment achieves sufficient adsorption efficiency while preserving the physical strength of the carrier material.
3Quantity of substance
If amino group content is increased to enhance adsorption capacity, then adsorption capacity is improved, but physical strength of the carrier material deteriorates
Solution Approach 1:
The patent changes the compositional parameters by specifying the types of amino groups and their content ratios rather than simply increasing total amino group content. This optimized composition achieves high adsorption capacity through efficient binding sites while maintaining carrier structural integrity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The adsorption material effectively adsorbs TGF-β or LAP-bound TGF-β, enhancing immune strength and potentially leading to tumor regression and cancer progression suppression, while maintaining the physical integrity of the carrier.
Implementation Method 1
a water-insoluble carrier to which at least one nitrogen-containing compound is bound... adsorbs TGF-β or LAP-bound TGF-β
Data Source
AI summary
An objective of the present disclosure is to provide an adsorption material that has a carrier material with retained physical strength, and efficiently adsorbs an immunosuppressive protein. The present disclosure provides an adsorption material for immunosuppressive protein. The adsorption material includes a water-insoluble carrier to which at least one nitrogen-containing compound selected from a polyamine represented by a predetermined formula and aliphatic amines represented by predetermined formulae is bound. A total content of amino groups on the water-insoluble carrier is more than 0 μmol and 2500 μmol or less per 1 g, and a content of primary amino groups on the water-insoluble carrier is 450 μmol or less per 1 g.