Ammonia-Lowering Components for Senescent Cell Removal
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Solution Overview
Problem
Existing methods for removing senescent cells, which contribute to aging and diseases, often have strong side effects and are not suitable for widespread use.
Innovation Solution
Promoting ammonia excretion in the body using substances like ornithine, citrulline, taurine, and lactulose to reduce the expression of senescent cell markers, thereby removing senescent cells and preventing aging.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional anticancer drugs are used to remove senescent cells, then senescent cell removal effectiveness is improved, but side effects become too strong for practical use
Solution Approach 1:
The patent converts the harmful accumulation of ammonia (a waste product of metabolism) into a beneficial mechanism for senescent cell removal. By promoting ammonia excretion through substances like ornithine, citrulline, and lactulose, the patent turns a harmful byproduct into a therapeutic lever to selectively eliminate senescent cells without the severe side effects of traditional anticancer drugs
Solution Approach 2:
The patent changes the physiological parameter of ammonia levels in the body by introducing substances that alter ammonia metabolism and excretion. This parameter change creates a selective pressure that removes senescent cells while maintaining safety, as the approach modifies metabolic parameters rather than using cytotoxic anticancer agents
2Object-affected harmful factors
If ammonia excretion is promoted to remove senescent cells, then side effects are reduced, but the mechanism complexity increases
Solution Approach 1:
The patent employs substances that leverage the body's existing ammonia metabolism and excretion pathways. Rather than introducing complex external systems, the invention uses compounds like ornithine and citrulline that naturally participate in the urea cycle, and lactulose that utilizes intestinal bacterial metabolism, allowing the body's own mechanisms to do the work of senescent cell removal
Data Source
AI summary
A method of removing senescent cells present in a living body with simpler method with fewer side effects. The method involves a mechanism of maintaining the survival of senescent cells by ammonia which is generated in excess through metabolism and the promotion of ammonia excretion enables the removal of senescent cells. When a component having capable of excreting ammonia is administered to aged mice, the expression level of p21, a marker of senescent cells, significantly decreases. Thus, removing the senescent cells can be achieved by administering a component for removing ammonia.