Ammonia-Oxidizing Microorganisms for Skin Microbiome Aging Control
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Solution Overview
Problem
There is a need for effective methods to maintain and improve skin health by modulating the skin microbiome, preventing skin aging, inflammation, and injury, while addressing topographical changes and maintaining skin integrity.
Innovation Solution
Administering an effective amount of ammonia oxidizing microorganisms (AOM) to the skin, which can include bacteria such as Nitrosomonas eutropha, to condition, modulate, and treat non-diseased skin, thereby preventing or inhibiting skin aging, inflammation, and maintaining skin integrity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional skincare methods are used, then skin basic functions are maintained, but skin aging, inflammation, and microbiome imbalance progress
Solution Approach 1:
The patent introduces ammonia oxidizing microorganisms that colonize the skin and autonomously perform beneficial functions: consuming ammonia, producing nitrite and NO, modulating the microbiome, and regulating inflammation. These microorganisms provide continuous self-service therapeutic effects without requiring repeated external intervention, thereby maintaining skin health while preventing aging and inflammation.
Solution Approach 2:
The ammonia oxidizing microorganisms act as intermediaries between the skin environment and the host immune system. They consume ammonia (a harmful byproduct), produce beneficial compounds (nitrite, NO), and modulate the microbiome, thereby mediating protective effects against skin aging, inflammation, and damage while maintaining basic skin functions.
2Ease of operation
If topical treatments are applied frequently, then skin conditions are treated, but skin microbiome balance is disrupted
Solution Approach 1:
Instead of requiring frequent external treatments that may disrupt the microbiome, the patent introduces ammonia oxidizing microorganisms that establish themselves on the skin and provide continuous therapeutic effects. These microorganisms autonomously consume ammonia, produce beneficial compounds, and modulate the microbiome over time, reducing the need for frequent external interventions while maintaining microbiome stability.
3Quantity of substance
If ammonia accumulates on skin, then natural metabolic process occurs, but skin inflammation and aging accelerate
Solution Approach 1:
The patent converts the harmful effect of ammonia accumulation into a beneficial process by introducing ammonia oxidizing microorganisms. These microorganisms consume the accumulated ammonia (the harmful substance) and convert it into beneficial compounds (nitrite and NO) that have anti-inflammatory and anti-aging effects. Thus, the presence of ammonia triggers a protective response rather than causing damage.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
AOM administration enhances skin health by promoting firmness, elasticity, radiance, and hydration, reducing wrinkles and inflammation, and maintaining skin integrity by modulating the skin microbiome and regulating nitrite and NO levels.
Implementation Method 1
ammonia oxidizing microorganisms (AOM)... regulating nitrite and NO levels
Data Source
AI summary
A method of preventing progression of an appearance or effect of aging in a subject is provided. A method of preventing, limiting, or inhibiting injury to skin integrity in a subject is also provided. A method of substantially maintaining a state of skin integrity in a subject is further provided. A method of preventing a topographical change of a cutaneous layer of skin in a subject is still further provided. The methods comprise administering an effective amount of a preparation comprising ammonia oxidizing microorganisms to the subject. Related preparations and kits are also provided.