Amnion Tissue Delivery via Temporary Stent Support
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current methods for delivering amnion tissue during surgery are challenging due to issues with permanent implant complications such as breakage, graft delamination, thrombus formation, infection, and foreign body reactions, and existing techniques do not efficiently utilize the therapeutic benefits of amnion for healing without causing inflammation.
Innovation Solution
A catheter-based delivery system using an extendable element, such as a stent or balloon, to deploy amnion tissue minimally invasively, where the tissue is mounted over the extendable section, allowing for deployment at a selected location within the body and subsequent removal of the delivery mechanism, leaving the amnion tissue in place with optional biological glue for adherence.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If permanent implant methods are used to deliver amnion tissue, then the tissue can be securely placed at the target location, but complications such as breakage, graft delamination, thrombus formation, infection, and foreign body reactions occur
Solution Approach 1:
The patent extracts the temporary support function from permanent implant structures. The deliverable support structure provides necessary support during tissue placement but is designed to be removed after serving its temporary purpose, eliminating the long-term complications associated with permanent implants while maintaining secure placement during the critical healing period
Solution Approach 2:
The deliverable support structure is discarded after fulfilling its temporary function of supporting amnion tissue placement. The structure is designed to be removed once the tissue has integrated or healed, preventing long-term complications while ensuring reliable initial placement. This aligns with the patent's approach of using temporary rather than permanent support structures
2Reliability
If traditional surgical methods are used to implant amnion tissue, then the tissue can be delivered to the target location, but the procedure is invasive and carries higher risk
Solution Approach 1:
The patent introduces a catheter-based delivery system as an intermediary mechanism to transport the amnion tissue and support structure to the target location through minimally invasive access. This intermediary delivery system allows the tissue to be placed at the desired location without requiring open surgery, reducing invasiveness while maintaining reliable delivery
Solution Approach 2:
The patent replaces traditional mechanical surgical implantation methods with a catheter-based delivery system. Instead of using surgical instruments and open procedures, the system uses a flexible catheter that can navigate to the target location and deploy the tissue through minimal incisions, substituting invasive mechanical surgery with a less invasive catheter-based approach
3Object-affected harmful factors
If extendable support structures are used to deliver amnion tissue minimally invasively, then surgical risk is reduced, but the complexity of the delivery system increases
Solution Approach 1:
The patent employs a nested structure where the amnion tissue is mounted on an extendable support structure that is itself contained within a deliverable catheter system. The support structure can be collapsed or compressed to fit within the catheter during delivery, then expanded at the target location to provide support. This nesting approach allows complex functionality to be delivered through a minimally invasive catheter without requiring equally complex deployment mechanisms
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables the secure, minimally invasive delivery of amnion tissue to specific locations within the body, reducing complications associated with permanent implants and leveraging the therapeutic benefits of amnion for healing while avoiding inflammation and foreign body reactions.
Implementation Method 1
the self-extending mechanical element comprises a shape memory metal configured to transition to the extended configuration
Implementation Method 2
The amnion tissue can have a biological glue on its outer surface to adhere the tissue to the patient upon deployment
Data Source
AI summary
An amnion tissue delivery system for delivering amnion tissue into a location within a patient is described. The location within a patient may be a tube, vessel, lumen, orifice, fistula, aneurysm, or chamber. The amnion tissue delivery system employs a catheter and extendable element, such as a removable stent-like structure, in a configuration such that extension of the extendable section deploys the amnion tissue at the desired location. A method for delivery of amnion tissue within a patient is also described. The method includes placing the catheter within the patient using a minimally invasive, endoluminal and/or extraluminal procedure to position tissue, followed by deploying the extendable element to deliver the amnion tissue at the desired location.