Decellularized Amniotic Membrane Composite for Tissue Repair
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Solution Overview
Problem
The high cost and limited mechanical properties of preserved amniotic membranes hinder their widespread use in tissue repair, as existing preservation methods either degrade bioactive factors or compromise the natural structure of the membrane.
Innovation Solution
A composite membrane is created by combining a decellularized amniotic membrane with a polymer fiber layer, which is attached without an adhesive, providing improved mechanical properties and retaining the biological functions of the amniotic membrane.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If wet preservation method is used for amniotic membrane, then the mechanical properties and structure are well preserved, but the cost is high and storage is difficult
Solution Approach 1:
The patent changes the preservation parameter from wet state to dry state by controlling the water content at or below 60%, thereby improving storage stability and reducing costs while maintaining structural integrity through optimized drying conditions
Solution Approach 2:
The patent creates a composite structure combining amniotic membrane with support materials or coating layers that enhance mechanical properties in the dry state, allowing the membrane to maintain strength without requiring wet preservation conditions
2Ease of manufacture
If lyophilization preservation is used for amniotic membrane, then the storage cost is reduced, but the mechanical properties deteriorate and the membrane becomes fragile
Solution Approach 1:
The patent applies composite material strategies by combining the amniotic membrane with reinforcing support layers or cross-linked structural components that prevent fragility during lyophilization, maintaining both low storage cost and adequate mechanical strength
Solution Approach 2:
The patent optimizes the water content parameter to specifically 60% or below, which prevents excessive dehydration that causes fragility while still enabling cost-effective dry storage through controlled drying processes
3Strength
If chemical or enzymatic cross-linkers are used to improve mechanical properties, then the stability and handleability are improved, but the bioactive matters are lost and biocompatibility is reduced
Solution Approach 1:
The patent employs disposable, biocompatible support materials that provide temporary mechanical reinforcement during handling and storage, then naturally degrade or are removed without leaving harmful residues, avoiding the need for persistent chemical cross-linkers
Solution Approach 2:
The patent uses physical support structures or reversible binding agents as intermediaries that provide mechanical stability during storage and handling, then can be easily removed or degraded without causing bioactive matter loss or biocompatibility issues
4Quantity of substance
If amniotic extracts or hydrogel forms are used, then the active substances are retained, but the natural structure is completely destroyed
Solution Approach 1:
The patent segments the amniotic membrane into preserved structural components that maintain their natural architecture, allowing the active substances to remain associated with their native structural context rather than being extracted into hydrogel form
Data Source
AI summary
The present invention relates to the field of biomedical technology, and relates to a composite membrane comprising a decellularized amniotic membrane, a use of the composite membrane, and a method for preparing the composite membrane.