Amniotic Tissue Wound Cover for Moisture Retention and Microbial Barrier
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Solution Overview
Problem
Existing wound covers do not effectively maintain a moist healing environment while preventing microbial contamination, and they are not suitable for long-term storage under normal conditions.
Innovation Solution
A wound cover composed of multiple layers, including polyester fabric, petroleum jelly, and deactivated non-viable amniotic tissue, which creates a moist environment, prevents microbial entry, and maintains structural integrity, allowing for long-term storage and application.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If a wound cover uses only petroleum jelly and polyester fabric to maintain moisture, then moisture retention is improved, but microbial protection is insufficient
Solution Approach 1:
The wound cover employs a composite multi-layer structure combining deactivated non-viable amniotic tissue (DNAT) with petroleum jelly and polyester fabric. The DNAT layer serves as a biological barrier against microbes while the petroleum jelly layers maintain moisture, creating a reliable healing environment that addresses both microbial protection and moisture retention simultaneously.
Solution Approach 2:
The deactivated non-viable amniotic tissue acts as an intermediary barrier layer between the external environment and the wound. This DNAT layer specifically targets microbial contamination while allowing the petroleum jelly to maintain moisture, thus resolving the contradiction between moisture retention and microbial protection.
2Reliability
If amniotic membrane is used as a wound cover, then healing substances are provided, but storage under normal conditions is not possible
Solution Approach 1:
The amniotic membrane undergoes a parameter change through dehydration and sterilization processes that convert it into deactivated non-viable amniotic tissue (DNAT). This transformation removes water and biological activity, enabling long-term storage under normal conditions while preserving the structural integrity and healing-promoting properties of the amniotic tissue.
Solution Approach 2:
The invention creates a disposable wound cover using deactivated amniotic tissue that can be stored long-term under normal conditions. The DNAT layer provides healing benefits through its physical barrier properties and residual bioactive molecules, while its deactivated state ensures stability for extended storage without special conditions.
3Duration of action of moving object
If a wound cover is designed for long-term wear, then healing time is extended, but structural strength must be maintained
Solution Approach 1:
The wound cover combines multiple materials with complementary properties: the DNAT layer provides biological compatibility and barrier function, the petroleum jelly layers provide moisture retention and flexibility, and the polyester fabric layers provide mechanical strength and structural integrity. This composite structure enables the wound cover to maintain strength throughout extended wear periods.
Solution Approach 2:
The wound cover is segmented into multiple functional layers, each contributing to overall structural integrity. The polyester fabric layers provide tensile strength and prevent tearing, while the intermediate DNAT and petroleum jelly layers maintain flexibility and adherence. This segmentation allows the wound cover to withstand long-term wear without compromising structural strength.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The wound cover supports natural healing processes by maintaining optimal moisture and preventing microbial contamination, facilitating faster healing of difficult-to-heal wounds without causing allergic reactions or skin irritation.
Implementation Method 1
thanks to their hydrophobic surface they do not allow moisture to escape from the wound, thereby contributing to the creation of a moist healing environment in the wound
Implementation Method 2
A test carried out according to EN ISO 22612:2005 compared a wound dressing containing only layers of polyester fabric and petroleum jelly, which resulted in the presence of such an amount of microbes that the colonies (CFU) could not even be counted, and a wound dressing according to the invention, which resulted in the presence of only an amount of microbes corresponding to 28 CFU, which represented a reduction of more than 6 logs of microbes passing through the wound dressing
Data Source
AI summary
The invention provides a wound cover, which contains, in the following order: - a first layer of polyester fabric, - a first layer of petroleum jelly, - a layer of deactivated non-viable amniotic tissue (DNAT), - a second layer of petroleum jelly, - a removable second layer of polyester fabric, which is configured to be removed before applying the wound cover to a wound. The wound cover is suitable for healing acute as well as chronic wounds. It provides a suitable environment supporting the healing of the wound. The invention further provides a method of manufacturing the wound cover.