Amorphous Cannabis Aerosol Composition for High-Load Delivery
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Solution Overview
Problem
Existing delivery systems for cannabis constituents, derivatives, or extracts face limitations in solubility and efficiency, particularly in liquid vaping systems, leading to suboptimal delivery of high levels of these materials.
Innovation Solution
The use of an amorphous solid composition comprising gelling agent, solvent, aerosol-former material, and cannabis constituents, derivatives, or extracts, which can be formulated to include higher concentrations of cannabis compounds, enhancing delivery efficacy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If liquid vaping systems are used to deliver cannabis constituents, then the delivery mechanism is simple and easy to operate, but the solubility and efficiency of delivering high levels of cannabis materials are limited
Solution Approach 1:
The patent changes the physical state of the cannabis compound from crystalline to amorphous form, which fundamentally alters its solubility parameters. The amorphous state eliminates the ordered crystal lattice structure, allowing for significantly higher solubility in the vaping liquid matrix. This parameter change enables the system to achieve both high concentration (improving_feature) and reliable delivery (worsening_feature) simultaneously, as the amorphous compounds dissolve more completely and consistently than their crystalline counterparts.
Solution Approach 2:
The patent creates a composite material system where amorphous cannabis compounds are integrated into a vaping liquid matrix containing carriers, solvents, and flavoring agents. This composite approach allows the amorphous active ingredient to be stabilized within the liquid medium while maintaining high solubility. The composite structure enables the system to deliver high levels of cannabis material reliably, as the amorphous form prevents recrystallization and ensures consistent dissolution during vaping.
2Quantity of substance
If higher concentrations of cannabis compounds are incorporated into the delivery system, then the potency and effectiveness increase, but the solubility and stability of the composition deteriorate
Solution Approach 1:
The patent applies parameter change by transforming the cannabis compound into amorphous form, which fundamentally alters its physical and chemical properties. The amorphous state eliminates the rigid crystal lattice that limits solubility and causes premature precipitation. This parameter transformation allows the system to incorporate high concentrations of cannabis compounds while maintaining stability, as the amorphous molecules remain dissolved in the liquid matrix without forming precipitates or separating phases.
Solution Approach 2:
The patent introduces intermediary substances (carriers and solvents) that mediate between the cannabis compounds and the vaping liquid matrix. These intermediaries facilitate the dissolution and stabilization of high concentrations of amorphous cannabis material. The carriers and solvents act as bridging agents that prevent direct interaction between cannabis molecules that would lead to recrystallization, thereby maintaining both high concentration and stability in the composition.
3Stability of the object's composition
If crystalline forms of cannabis compounds are used, then the material is stable and easy to handle, but the solubility and delivery efficiency are reduced
Solution Approach 1:
The patent applies parameter change by converting the cannabis compound from crystalline to amorphous form, fundamentally altering its physical properties. The amorphous state eliminates the ordered crystal lattice structure that characterizes crystalline materials. This parameter transformation resolves the contradiction between stability and delivery efficiency: the amorphous form maintains stability through molecular stabilization in the liquid matrix while simultaneously achieving superior delivery efficiency through enhanced solubility and complete dissolution during vaping.
Solution Approach 2:
The patent exploits phase transition by transforming the cannabis compound from the crystalline phase to the amorphous phase. This phase transition is achieved through specific processing methods that prevent crystal formation during drying or cooling. The amorphous phase exhibits fundamentally different properties compared to the crystalline phase, including higher solubility, faster dissolution rates, and improved bioavailability, thereby resolving the contradiction between material stability and delivery efficiency.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The amorphous solid composition allows for higher incorporation and delivery of cannabis constituents, derivatives, or extracts, providing improved inhalable aerosol generation and oral delivery solutions.
Implementation Method 1
The heating volatilises at least one component of the material, typically forming an inhalable aerosol
Implementation Method 2
a liquid source (which may or may not contain nicotine) which is vaporised by heating to produce an inhalable vapour or aerosol
Data Source
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AI summary
The present invention provides an amorphous solid for use in aerosol generation, the amorphous solid comprising: about 1 to about 12 wt% constituent, derivative or extract of cannabis; about 10 to about 80 wt% aerosol-former material; gelling agent; and optionally filler, wherein the amount of gelling agent and optional filler taken together is from about 10 to about 60 wt%; wherein the wt% values are calculated on a dry weight basis.