Amorphous Solid Cannabis Aerosol Composition
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Solution Overview
Problem
Current methods for delivering cannabis constituents, such as CBD, in aerosol form face limitations due to solubility issues in liquid vaping systems, leading to suboptimal delivery of high levels of these compounds.
Innovation Solution
An amorphous solid composition comprising 1-50 wt% cannabis constituents, 10-80 wt% aerosol-former materials like glycerol, and gelling agents including cellulose derivatives, which forms a monolithic solid capable of generating aerosols when heated, allowing for higher delivery of cannabis compounds.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If liquid vaping systems are used to deliver cannabis constituents, then the delivery mechanism is simple, but the solubility of cannabis compounds is limited
Solution Approach 1:
The patent changes the physical state of the cannabis compound delivery system from liquid to amorphous solid. This parameter change allows cannabis constituents to be delivered at higher concentrations (1-50 wt%) without solubility limitations, as the amorphous solid matrix does not require dissolution in a liquid medium to release the active compounds during heating.
Solution Approach 2:
The patent creates a composite amorphous solid material comprising cannabis constituents combined with aerosol-forming materials and gelling agents. This composite structure enables the integration of multiple functions: the cannabis provides the active compound, the aerosol-forming materials enable vaporization, and the gelling agents provide structural stability, collectively resolving the solubility limitation while maintaining reliable delivery.
2Quantity of substance
If high levels of cannabis compounds are delivered, then the therapeutic effect is improved, but the solubility limitations in liquid systems prevent effective delivery
Solution Approach 1:
By transitioning from liquid to amorphous solid formulation, the patent enables incorporation of high levels of cannabis compounds (1-50 wt%) without the solubility constraints that limit liquid systems. The amorphous solid state provides a stable matrix that maintains formulation integrity while allowing high active compound loading.
Solution Approach 2:
The patent introduces gelling agents as intermediary materials that stabilize the amorphous solid structure containing high concentrations of cannabis compounds. These gelling agents act as a mediating matrix that maintains formulation stability while enabling high levels of active compound incorporation, resolving the conflict between quantity and manufacturability.
3Quantity of substance
If amorphous solid composition is used, then higher cannabis compound delivery is achieved, but the manufacturing process becomes more complex
Solution Approach 1:
The patent employs composite materials comprising cannabis constituents, aerosol-forming materials, and gelling agents in an amorphous solid matrix. This composite approach enables high cannabis compound concentration (1-50 wt%) while the combination of components works synergistically to simplify the overall formulation process compared to attempting to dissolve high concentrations in liquid systems.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The amorphous solid composition enables the efficient delivery of higher cannabis compound levels by forming a monolithic solid that aerosolizes effectively when heated, overcoming solubility limitations in traditional vaping systems.
Implementation Method 1
The amorphous solid composition enables the efficient delivery of higher cannabis compound levels by forming a monolithic solid that aerosolizes effectively when heated
Implementation Method 2
gelling agent, the gelling agent comprising cellulose or a derivative thereof, and a non-cellulosic gelling agent
Data Source
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AI summary
The present invention provides an amorphous solid for use in aerosol generation, the amorphous solid comprising: about 1 to about 50 wt% constituent, derivative or extract of cannabis; about 10 to about 80 wt% aerosol-former material; gelling agent, the gelling agent comprising cellulose or a derivative thereof, and a non-cellulosic gelling agent; and optionally filler, wherein the amount of gelling agent and optional filler taken together is from about 10 to about 60 wt%; wherein the wt% values are calculated on a dry weight basis.